| p53(+/+) | p53 |
|---|---|
| p53-/- | p53 deficient |
| wt-p53 | Wild-type p53 |
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| p53 | <molecular biology, oncogene> A gene which encodes a protein that regulates cell growth and is able to cause potentially cancerous cells to destroy themselves. In humans it is a 393 residue phosphoprotein that is a tumour suppressor gene rather than an oncogene, as it is frequently inactivated or mutated in tumours and transformed cells. The gene is an antioncogene, and is often found mutated in smokers with lung cancer by a compound found in tobacco smoke, a polycyclic aromatic hydrocarbon called benzo[a]pyrene. The protein it encodes is a phosphoprotein that is 53 kilodaltons in mass. (24 Mar 1998) |
|---|---|
| p53-activating kinase | <enzyme> Regulates p53 activity in saccharomyces cerevisiae; 810 amino acid residues; genbank u24167; do not confuse with pak I, protease-activated kinase Registry number: EC 2.7.10.- Synonym: pak1 gene product, yeast pak1 (26 Jun 1999) |
| genes, p53 | Tumour suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53. (12 Dec 1998) |
|---|---|
| protein p53 | Nuclear phosphoprotein encoded by the p53 gene (genes, p53) whose normal function is to control cell proliferation. A mutant or absent p53 protein has been found in leukaemia, osteosarcoma, lung cancer, and colourectal cancer. (12 Dec 1998) |
| p53 |
a cell cycle related transcription factor that promotes transcription of genes that induce cell cycle arrest or apoptosis in response to DNA damage or other cell stresses. This tumor suppressor gene is mutated in about half of all human cancers. Nomenclature is p for protein and 53 is molecular size (53,000 daltons). (More? Week 1 Mitosis) See also : OMIM Entry for p53
Ãâó: embryology.med.unsw.edu.au/Notes/Index/P.htm
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| p53 |
A suppressor gene. Certain genetic mutations in p53 cause li-fraumeni syndrome. Source : PhRMA Genomics
Ãâó: www.genomecanada.ca/GCglossaire/glossaire/index.as...
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| p53 |
A gene in the cell that normally inhibits the growth of tumors, which can prevent or slow the spread of cancer.
Ãâó: www3.mdanderson.org/focus/breast/glossary/DEFS_MP....
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| p53 |
a protein that appears to have anti-oncogenic properties. See What is p53?
Ãâó: www.madison.k12.wi.us/west/science/biotech/vocabul...
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| p53 |
A tumor suppressor gene that is mutated in many human cancers and results in the loss of a cell뭩 ability to check for DNA damage.
Ãâó: www.knowledgene.com/public/glossary_content.php3
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