| ovarian stromal tumours | <radiology> Age 20 - 50 yrs, 20% of all ovarian tumours, fibroma / fibrosarcoma, granulosa-theca cell tumour, with or without oestrogens most likely to be precocious puberty, endometrial hyperplasia/carcinoma, fibrocystic breast disease, Sertoli-Leydig cell tumour, aka: arrhenoblastoma, with or without androgens most likely to be masculinization, may be mixed type (12 Dec 1998) |
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| sarcoma, endometrial stromal | A highly malignant neoplasm of the endometrium, arising from the endometrial stroma. It represents one type of stromal tumour, the other being endolymphatic stromal myosis. They are differentiated on the basis of the number of mitoses per 10 high power fields: endometrial stromal sarcoma has 10 or more mitoses, endolymphatic stromal myosis fewer. Stroma sarcoma is seen most often between the ages of 45 and 50. (devita jr et al., cancer: principles & practice of oncology, 3d ed, p1146) (12 Dec 1998) |
| sex cord-stromal tumour | A malignant neoplasm of the ovary or testis. These tumours differentiate toward sex cords (in embryonic gonads) in the form of female (i.e., granulosa and theca) cells, male (i.e., sertoli and leydig) cells, or indifferent elements. In the ovary, sex cord-stromal tumours comprise 5% of all ovarian neoplasms. In the testes, leydig and sertoli cell tumours comprise about 5% of all testicular neoplasms, 10% of which behave in a malignant fashion. (12 Dec 1998) |
| stromal | Stromatic; relating to the stroma of an organ or other structure. Synonym: stromic. (05 Mar 2000) |
| stromal cells | Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the haematopoietic system and elsewhere. (12 Dec 1998) |
| stromal hyperthecosis | Condition in which luteinised cells are present in ovarian stroma at a distance from follicular structures. (05 Mar 2000) |
| stromal processing peptidase | <enzyme> Involved in processing chloroplast stromal proteins Registry number: EC 3.4.24.- (26 Jun 1999) |
| endometrial stromal sarcoma | <tumour> A term sometimes used for a relatively rare sarcoma believed to be a form of endometriosis in which the lesions form multiple foci in the myometrium and in vascular spaces in other sites, and which consist of histologic and cytologic elements that resemble those of the endometrial stroma. Synonym: stromatosis. (05 Mar 2000) |
| adrenal hyperplasia | <pathology> A condition of diffuse enlargement of the adrenal glands. Origin: Gr. Plassein = to form (27 Sep 1997) |
| adrenal hyperplasia, congenital | A group of inherited disorders of adrenal steroidogenesis, the physical expression of which varies with the sex of the patient, the severity of the congenital enzyme defect, and the age at which the defect makes its presence felt. The most common form, the simple virilizing form, is due to a 21-hydroxylase deficiency. There is also a salt-losing form (a more complete 21-hydroxylase deficiency), a hypertensive form (11-hydroxylase deficiency), a 17-hydroxylase deficiency form, a desmolase deficiency form, and a 3-beta-hydroxysteroid deficiency form. (12 Dec 1998) |
| angiofollicular mediastinal lymph node hyperplasia | Solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes, occurring usually in the mediastinum or hilar region of young adults; similar changes have been reported outside the mediastinum and, if associated with interfollicular sheets of plasma cells, may progress to lymphoma or plasmacytoma. Synonym: angiofollicular mediastinal lymph node hyperplasia, Castleman's disease. (05 Mar 2000) |
| angiolymphoid hyperplasia with eosinophilia | Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells. (12 Dec 1998) |
| atypical melanocytic hyperplasia | Proliferation of melanocytes showing nuclear atypicality, especially as scattered single cells high in the epidermis; interpreted by some pathologists as malignant melanoma in situ. (05 Mar 2000) |
| basal cell hyperplasia | Increase in the number of cells in an epithelium resembling the basal cells. (05 Mar 2000) |
| benign giant lymph node hyperplasia | Solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes, occurring usually in the mediastinum or hilar region of young adults; similar changes have been reported outside the mediastinum and, if associated with interfollicular sheets of plasma cells, may progress to lymphoma or plasmacytoma. Synonym: angiofollicular mediastinal lymph node hyperplasia, Castleman's disease. (05 Mar 2000) |