| osmotic fragility |
susceptibility of erythrocytes to rupture when subjected to increasingly hypotonic saline solutions; seen in some forms of hemolytic anemia and spherocytosis. See also osmotic fragility test, under test.
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| osmotic fragility t. |
(for spherocytosis): heparinized or defibrinated blood is placed in tubes of sodium chloride solution (pH 7.4) varying in concentration from 0.85 to 0.00 per cent (w/v); the amount of hemolysis in each tube is determined colorimetrically. Increased fragility indicates spherocytosis.
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