| orotidine |
a nucleoside, orotic acid linked by its N1 nitrogen to the C1 carbon of ribose; a phosphorylated derivative, orotidine 5′-phosphate, is an intermediate in pyrimidine nucleotide biosynthesis.
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| orotidine-5’-phosphate decarboxylase |
[EC 4.1.1.23] an enzyme of the lyase class that catalyzes the decarboxylation of orotidine 5′-phosphate to form uridine monophosphate in the synthesis of pyrimidine nucleotides. The catalytic sites for this activity and for the orotate phosphoribosyltransferase (OPRT) activity are on a single protein. Deficiency of ODC activity only, an autosomal recessive trait, results in oroticaciduria, type II.
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