| orotate |
a dissociated form of orotic acid.
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| orotate phosphoribosyltransferase |
[EC 2.4.2.10] an enzyme activity of the transferase class that catalyzes the transfer to orotate of a ribosyl group from phosphoribosylpyrophosphate (PRPP) to form orotidine 5′-phosphate as a step in the synthesis of pyrimidine nucleotides. The catalytic sites for this activity and for orotidine 5′-phosphate decarboxylase (ODC) activity occur on a single protein, called UMP synthase; deficiency of both activities, an autosomal recessive trait, causes hereditary oroticaciduria type I.
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