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organ-specific a. any antigen that occurs exclusively in a particular organ and serves to distinguish it from other organs. Two types of organ specificity have been proposed: (1) first-order or tissue specificity is attributed to the presence of an antigen characteristic of a particular organ in a single species; (2) second-order organ specificity is attributed to an antigen characteristic of the same organ in many, even unrelated species. Called also tissue-specific a.
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