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Oncogene Proteins v-erbA - 새창
Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.
Synonyms : Oncogene Products v-erbA, Oncogene Products v erbA, Oncogene Proteins v erbA, v erbA Proteins
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