| oligomycin | <microbiology> A bacterial toxin inhibitor of oxidative phosphorylation that acts on a small subunit of the F1 ATPase. (18 Nov 1997) |
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| oligomycin sensitivity conferral protein | <protein> The _ subunit of the ATP synthase, believed to link the F1 catalytic segment to the F0 proton conduction segment. Binds the toxin oligomycin. (18 Nov 1997) |
| oligomycins | <chemical> A closely related group of toxic substances elaborated by various strains of streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various atpases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are rutamycin, peliomycin, and botrycidin (formerly venturicidin x). Pharmacological action: antibiotics, macrolide, enzyme inhibitors, uncoupling agents. (12 Dec 1998) |