| nonsense strand | <molecular biology> DNA that does not code for part of a polypeptide chain or RNA.This includes introns and pseudo genes. In eukaryotes the majority of the DNA is noncoding. Noncoding strand refers to the so called nonsense strand, as opposed to the sense strand which is actually translated into mRNA. (18 Nov 1997) |
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| codon, nonsense | A codon that is not assigned to an amino acid or to any stop signal. It was originally thought that nonsense codons were synonymous with terminator codons (codon, terminator) in that they signaled termination of a protein chain. Recent studies have found this not to be true. (12 Dec 1998) |
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| nonsense | As used in genetics, relating to a mutation that causes a sequence such that the growing peptide chain terminates, often after several incorrect amino acid residues are incorporated. (05 Mar 2000) |
| nonsense codon | <molecular biology> The three codons, UAA (known as ochre), UAG (amber) and UGA (opal), that do not code for an amino acid but act as signals for the termination of protein synthesis. Any mutation that causes a base change which produces a nonsense codon results in premature termination of protein synthesis and probably a nonfunctional or nonsense protein. (13 Nov 1997) |
| nonsense mutation | <molecular biology> A mutation that causes a polypeptide chain to be ended prematurely. (13 Nov 1997) |
| nonsense suppression | Mutant tRNAs that read a chain termination codon as the signal for incorporation of a specific amino acid residue. (05 Mar 2000) |
| nonsense syndrome | <syndrome> A psychotic-like condition, without the symptoms and signs of a traditional psychosis, occurring typically in prisoners who feign insanity; e.g., such a person, when asked to multiply 6 by 4, will give 23 as the answer, or he will call a key a lock. See: malingering, factitious disorder. Synonym: nonsense syndrome, syndrome of approximate relevant answers, syndrome of deviously relevant answers. (05 Mar 2000) |
| nonsense triplet | A trinucleotide (codon) in which a base change to a termination codon results in premature termination of the growing polypeptide chain and, consequently, incomplete protein molecules, a termination codon. (05 Mar 2000) |
| anticoding strand | The strand of duplex DNA which is used as a template for the synthesis of mRNA. Synonym: antisense strand. (05 Mar 2000) |
| antiparallel strand | A macromolecular strand that is oriented in the opposite direction of a neighboring strand. (05 Mar 2000) |
| antisense strand | <molecular biology> The strand of DNA which is not used during transcription to make mRNA (anticoding strand). The mRNA made during transcription thus has the same sequence as this strand, so that the eventual protein will be a sense version. (13 Jan 1998) |
| ATP-dependent DNA strand transferase | <enzyme> From human cell nuclei; catalyses strand exchange between homologous DNA sequences; magnesium dependent, requires ATP hydrolysis Registry number: EC 2.7.7.- Synonym: ATP-dep-DNA-str trnsfase (26 Jun 1999) |
| viral strand | See: replicative form. (05 Mar 2000) |
| minus strand | See: replicative form. (05 Mar 2000) |
| minus-strand nucleic acid | <molecular biology> An RNA or DNA strand which has the opposite sense of (would be complementary to) the mRNA of a virus. (12 Jan 1998) |
| coding strand | The strand of duplex DNA that has the same sequence as the mRNA (except that mRNA contains ribonucleotides instead of deoxyribonucleotides). Synonym: sense strand. (05 Mar 2000) |