| neurotrophic atrophy | Abnormalities of the skin, hair, nails, subcutaneous tissues and bone, caused by peripheral nerve lesions. Synonym: neuritic atrophy, neurogenic atrophy, neurotrophic atrophy, trophic changes. (05 Mar 2000) |
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| brain-derived neurotrophic factor | <growth factor> Small basic protein purified from pig brain, a member of the family of neurotrophic factors that also includes Nerve Growth Factor and neurotrophin 3. In contrast to nerve growth factor, brain-derived neurotrophic factor is predominanantly (though not exclusively) localised in the CNS. It supports the survival of primary sensory neurons originating from the neural crest and ectodermal placodes that are not responsive to NGF. In the brain brain-derived neurotrophic factor has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. Acronym: BDGF (12 Dec 1998) |
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| ciliary neurotrophic factor | <growth factor> Neurotrophic factor originally characterised as a survival factor for chick ciliary neurons in vitro. Subsequently shown to promote the survival of a variety of other neuronal cell types and to promote the differentiation of bipotential O2A progenitor cells to type 2 astrocytes in vitro. Molecular cloning and expression studies indicate that CNTF is a cytosolic protein. Developmental expression and regional distribution studies show that, unlike NGF, CNTF is not a target derived neurotrophic factor. (18 Nov 1997) |
| neurotrophic | Involved in the nutrition (or maintenance) of neural tissue. Classic example is nerve growth factor. (18 Nov 1997) |
| neurotrophic factor | A molecule, usually a protein, that will facilitate the growth or repair of nerve cells. (14 Nov 1997) |
| neurotrophic keratitis | Inflammation of the cornea after corneal anaesthesia. Synonym: neuroparalytic keratitis. (05 Mar 2000) |
| acute reflex bone atrophy | Atrophy of bones, commonly of the carpal or tarsal bones, following a slight injury such as a sprain. See: causalgia, reflex sympathetic dystrophy. Synonym: acute reflex bone atrophy, posttraumatic osteoporosis, Sudeck's syndrome. Origin: L. English sweat (05 Mar 2000) |
| acute yellow atrophy of the liver | A lesion in which there is extensive and rapid death of parenchymal cells of the liver, sometimes with fatty degeneration of the size of the organ; the necrosis may result from fulminant viral infection or chemical poisoning; associated with jaundice. Synonym: acute parenchymatous hepatitis, Rokitansky's disease. (05 Mar 2000) |
| alveolar atrophy | Diminution in size of the supportive tissues of the teeth due to lack of function, reduced blood supply, or unknown causes. (05 Mar 2000) |
| arthritic atrophy | Atrophy of muscles rendered inactive by a chronically inflamed or fixed joint. (05 Mar 2000) |
| atrophy | <pathology> A wasting away, a diminution in the size of a cell, tissue, organ or part. Origin: L., Gr. Atrophia (16 Dec 1997) |
| back-pressure renal atrophy | <radiology> Caliectasis without obstruction, due to repeated episodes of obstruction, gradual loss of renal pyramids (12 Dec 1998) |
| blue atrophy | Depressed blue atrophic scars due to injections in the skin of impure substances, as seen in narcotics addicts. (05 Mar 2000) |
| brown atrophy | Atrophy of the heart wall, especially in the elderly, in which the muscle is dark reddish brown and reduced in volume; the muscle fibres become pigmented especially about the nuclei, by lipochrome granules. (05 Mar 2000) |
| Buchwald's atrophy | A progressive form of cutaneous atrophy. (05 Mar 2000) |
| macular atrophy | Atrophoderma in which the skin becomes bag like and wrinkled. Synonym: atrophia maculosa varioliformis cutis, atrophoderma maculatum, macular atrophy, primary idiopathic macular atrophy, primary macular atrophy of skin. Origin: G. Anetos, relaxed, + derma, skin (05 Mar 2000) |