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NTs Neuropil threads
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neuropil A dense intricate feltwork of interwoven fine glial processes, fibrils, synaptic terminals, axons, and dendrites interspersed among the nerve cells in the gray matter of the central nervous system.
(12 Dec 1998)
neuropil threads Abnormal structures located chiefly in distal dendrites and, along with neurofibrillary tangles and senile plaques, constitute the three morphological hallmarks of alzheimer disease. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in alzheimer disease.
(12 Dec 1998)
neuropile The complex, feltlike net of axonal, dendritic, and glial arborizations that forms the bulk of the central nervous system's gray matter, and in which the nerve cell bodies lie embedded.
Origin: neuro-+ G. Pilos, felt
(05 Mar 2000)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 5 ÆäÀÌÁö: 1
  • Neuropil - »õâ A dense intricate feltwork of interwoven fine glial processes, fibrils, synaptic terminals, axons, and dendrites interspersed among the nerve cells in the gray matter of the central nervous system.
    Synonyms : Neuropile, Neuropiles, Neuropils
  • Neuropil Threads - »õâ Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.
    Synonyms : Neuropil Thread
  • Neuropilin-1 - »õâ Dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and axonal guidance. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS, and binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
    Synonyms : A5 Antigen, NRP1 Protein, Npn-1 Protein, Sema III Receptor, Semaphorin III Receptor, Antigen, A5, Neuropilin 1, Npn 1 Protein, Receptor, Sema III
  • Neuropilin-2 - »õâ Transmembrane receptor for CLASS 3 SEMAPHORINS and several vascular endothelial growth factor isoforms. Neuropilin-2 functions either as a homodimer or as a heterodimer with NEUROPILIN-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.
    Synonyms : NRP2 Protein, Npn-2 Protein, Neuropilin 2, Npn 2 Protein
  • Neuropilins - »õâ Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.
    Synonyms :
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neuropil a fibrous network of delicate unmyelinated nerve fibers interrupted by numerous synapses and found in concentrations of nervous tissue especially in parts of the brain where it is highly developed
Ãâó: virtualtrials.com/dictionary.cfm
neuropil (Gr. nerve felt): The feltwork of unmyelinated neuronal processes (axonal and dendritic) within the gray matter of the central nervous system.
Ãâó: www.umanitoba.ca/faculties/medicine/anatomy/neuro/...
neuropile neuropil.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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