neurofibroma : KMLE 의학 검색 엔진 - 의학사전, 의학용어, 의학약어, 의학논문, 약품/의약품 검색

MeSH(Medical Subject Headings) 맞춤 검색 (http://www.nlm.nih.gov) 결과 : 5 페이지: 1

Neurofibroma - 새창 A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)
Synonyms : Neurofibromas
Neurofibroma, Plexiform - 새창 A type of neurofibroma manifesting as a diffuse overgrowth of subcutaneous tissue, usually involving the face, scalp, neck, and chest but occasionally occurring in the abdomen or pelvis. The tumors tend to progress, and may extend along nerve roots to eventually involve the spinal roots and spinal cord. This process is almost always a manifestation of NEUROFIBROMATOSIS 1. (From Adams et al., Principles of Neurology, 6th ed, p1016; J Pediatr 1997 Nov;131(5):678-82)
Synonyms : Tumor Royale, Elephantiasis Neuromatoses, Neurofibromas, Plexiform, Neuroma, Plexiform, Pachydermatoceles, Plexiform Neurofibroma, Plexiform Neurofibromas, Plexiform Neuroma, Plexiform Neuromas
Neurofibromatoses - 새창 A group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. NEUROFIBROMATOSIS 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., NEUROFIBROMATOSIS 2, neurofibromatosis 3, etc.) have been described. (From Neurochirurgie 1998 Nov;44(4):267-72)
Synonyms : Multiple Neurofibromas, Neurofibromatosis 3, Neurofibromatosis Syndrome, Multiple Neurofibroma, Neurofibroma, Multiple, Neurofibromas, Multiple, Neurofibromatosis 3s, Neurofibromatosis Syndromes, Syndrome, Neurofibromatosis, Syndromes, Neurofibromatosis
Neurofibromatosis 1 - 새창 An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS).
Synonyms : NF1 (Neurofibromatosis 1), Neurofibromatosis I, Neurofibromatosis Type 1, Neurofibromatosis Type I, Neurofibromatosis, Peripheral, NF 1, Neurofibromatosis, Peripheral, NF1, Neurofibromatosis, Type 1, Neurofibromatosis, Type I, Recklinghausen's Disease of Nerve
Neurofibromatosis 2 - 새창 An autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas (NEURILEMMOMA) of other cranial and peripheral nerves, and other benign intracranial tumors including meningiomas, ependymomas, spinal neurofibromas, and gliomas. The disease has been linked to mutations of the NF2 gene (GENES, NEUROFIBROMATOSIS 2) on chromosome 22 (22q12) and usually presents clinically in the first or second decade of life.
Synonyms : Bilateral Acoustic Neurofibromatosis, Familial Acoustic Neuromas, NF2 (Neurofibromatosis 2), Neurofibromatosis II, Neurofibromatosis Type 2, Neurofibromatosis Type II, Neurofibromatosis, Central NF2, Neurofibromatosis, Central, NF 2, Neurofibromatosis, Type 2