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neurofibril A filamentous structure seen with the light microscope in the nerve cell's body, dendrites, axon, and sometimes synaptic endings, as aggregations of much finer ultramicroscopic elements, the neurofilaments and microtubules; their functional significance remains to be established.
(05 Mar 2000)
neurofibrillar Relating to neurofibrils.
(05 Mar 2000)
neurofibrillar nerve <anatomy, nerve> The intertwined patterns formed by neurofibrils in the neuron.
(05 Mar 2000)
neurofibrillary degeneration Formation of coarse, argentophilic, intracytoplasmic fibres, often in complex tangles within intracranial nerve cells that are undergoing aging.
See: Alzheimer's disease.
(05 Mar 2000)
neurofibrillary tangle <cell biology> Accumulation of twisted protein fragments inside nerve cells. Neurofibrillary tangles are one of the characteristic structural abnormalities found in the brains of patients with Alzheimer's disease patients.
Upon autopsy, the presence of neuritic plaquesand neurofibrillary tangles is used to positively diagnose Alzheimer's disease.
(22 May 1997)
neurofibrillary tangles Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: 1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; 2) the microtubule-associated proteins map-2 and tau; 3) actin; and 4) ubiquitin. As one of the hallmarks of alzheimer disease, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brainstem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of alzheimer disease.
(12 Dec 1998)
neurofibrils <cell biology> Filaments found in neurons, not necessarily neurofilaments in all cases and in the older literature fibrils are composed of both microtubules and neurofilaments. Originally used by light microscopists to describe much larger fibrils seen particularly well with silver staining methods.
(18 Nov 1997)
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  • Neurofibrillary Tangles - »õâ Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.
    Synonyms : Neurofibrillary Tangle, Tangle, Neurofibrillary, Tangles, Neurofibrillary
  • Neurofibrils - »õâ The delicate interlacing threads, formed by aggregations of neurofilaments and neurotubules, coursing through the cytoplasm of the body of a neuron and extending from one dendrite into another or into the axon.
    Synonyms : Neurofibril
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neurofibril node Ranvier's node.
Ãâó:
neurofibril any of the fibrils visible in the perikaryon, dendrites, and axon of a neuron in light microscopy after staining with silver; the fibrils are believed to be neurofilament bundles, and perhaps also neurotubules, that have become coated with silver particles.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
neurofibrilla pl. neurofibril´lae  Neurofibril.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
neurofibrillar pertaining to neurofibrils.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
neurofibrillar n. the network formed by the neurofibrils of a nerve cell.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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