| carcinoma, neuroendocrine | A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumours include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, merkel cell tumour, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumours, and pheochromocytoma. Neurosecretory granules are found within the tumour cells. (12 Dec 1998) |
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| primary neuroendocrine carcinoma of the skin | A rare malignant cutaneous tumour seen in sun-exposed skin of elderly patients composed of dermal nodules of small round cells with scanty cytoplasm in a trabecular pattern; the tumour cells contain cytoplasmic dense core granules resembling neurosecretory granules seen in Merkel cells. Synonym: primary neuroendocrine carcinoma of the skin, trabecular carcinoma. (05 Mar 2000) |
| neuroendocrine | 1. Pertaining to the anatomical and functional relationships between the nervous system and the endocrine apparatus. 2. Descriptive of cells that release a hormone into the circulating blood in response to a neural stimulus. Such cells may comprise a peripheral endocrine gland (e.g., the insulin-secreting beta cells of the islets of Langerhans in the pancreas and the adrenaline-secreting chromaffin cells of the adrenal medulla); others are neurons in the brain (e.g., the neurons of the supraoptic nucleus that release antidiuretic hormone from their axon terminals in the posterior lobe of the hypophysis). (05 Mar 2000) |
| neuroendocrine cell | <endocrinology> A hormone secreted by specialised neurons (neuroendocrine cells), for example releasing hormones. (18 Nov 1997) |
| neuroendocrine transducer cell | An endocrine cell that releases its hormonal product into the bloodstream only upon receipt of a nervous impulse. (05 Mar 2000) |
| neuroendocrine tumours | Tumours whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumours include ectopic hormone production (often via apud cells), the presence of tumour-associated antigens, and isozyme composition. (12 Dec 1998) |
| absorptive cells of intestine | Cell's on the surface of villi of the small intestine and the luminal surface of the large intestine that are characterised by having microvilli on their free surface. (05 Mar 2000) |
| air cells | Air-containing spaces in the skull. See: pulmonary alveolus. (05 Mar 2000) |
| air cells of auditory tube | Occasional small air cells in the inferior wall of the auditory tube, near the tympanic orifice, communicating with the tympanic cavity. Synonym: cellulae pneumaticae tubae auditivae, air cells of auditory tube. (05 Mar 2000) |
| Alpha cells | Alpha cell's of pancreas or of anterior lobe of hypophysis. (05 Mar 2000) |
| alpha cells of anterior lobe of hypophysis | Acidophil cell's that constitute about 35% of the cell's of the anterior lobe. There are two varieties: one that elaborates somatotropin, another that elaborates prolactin. (05 Mar 2000) |
| alpha cells of pancreas | Cell's of the islets of Langerhans that secrete glucagon. (05 Mar 2000) |
| amniogenic cells | Cell's from which the amnion develops. (05 Mar 2000) |
| anabiotic cells | Cell's that are capable of resuscitation after apparent death; the existence of anabiotic tumour cell's is postulated to explain the recurrence of a cancer after a very long symptomless period following operation. (05 Mar 2000) |
| angioblastic cells | Those cell's in the early embryo from which primitive blood cell's and endothelium develop. (05 Mar 2000) |