| myotonic | Pertaining to or exhibiting myotonia. (05 Mar 2000) |
|---|---|
| myotonic cataract | Cataract occurring in myotonic dystrophy. (05 Mar 2000) |
| myotonic dystrophy | <neurology> An inherited human neuromuscular disease classed as an autosomal dominant disease in which there is progressive muscle weakening and wasting. A triplet repeat syndromes (like fragile X syndrome), this most common adult form of muscular dystrophy is caused by expansion of the unstable trinucleotide repeat CTG in the 3' untranslated region on chromosome 19q13 (cAMP-dependent muscle protein kinase gene). Anticipation has been associated with further expansion of the repeat upon transmission to subsequent generations (the inheritance pattern is autosomal dominant), although contraction has been noted to occur as well. Especially severe neonatal cases have been born to affected mothers preferentially, suggesting a role for genomic imprinting as well. The classic physical signs include atrophy of facial muscles, cataracts, and delayed muscle relaxation. Detection of the expanded trinucleotide repeat is accomplished by PCR or Southern blot and expansion appears to correlate with decreased transcription of the protein kinase gene. Inheritance: autosomal dominant. (29 Dec 1997) |
| dystrophy, myotonic | Inherited disease with myotonia (irritability and prolonged contraction of muscles), mask-like face, premature balding, cataracts, and cardiac disease. Due to a trinucleotide repeat (a stuttering sequence of three bases) in the DNA. (12 Dec 1998) |
| accelerated reaction | A response occurring in a shorter time than expected; the cutaneous manifestations occurring during the period between the second and tenth day following smallpox vaccination; because it is intermediate between a primary reaction and an immediate reaction, it is regarded as evidence of some degree of resistance. Synonym: vaccinoid reaction. (05 Mar 2000) |
| acid reaction | Any test by which an acid reaction is recognised such as the change of blue litmus paper to red, an excess of hydrogen ions over hydroxide ions in aqueous solution indicated by a pH value less than 7 (at 22캜). Compare: dissociation constant of water. (05 Mar 2000) |
| acute-phase reaction | <immunology, rheumatology> Refers to the changes in synthesis of certain proteins within the serum during an inflammatory response, which provides rapid protection for the host against microorganisms via non-specific defense mechanisms. It consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma; the reaction is mediated by endogenous pyrogens, the hypothalamus, adrenal hormones, and other factors. (12 Jul 2000) |
| acute situational reaction | An acute emotional reaction related to extreme environmental stress. Synonym: acute situational reaction. (05 Mar 2000) |
| acute stress reaction | A sudden bout of anxiety that is often accompanied by the features of hyperventilation (tingling around mouth and in fingertips, rapid breathing, faintness or fainting). (27 Sep 1997) |
| addition reaction | <chemistry> Any reaction in which two chemicals combine to form a single chemical. (15 Jan 1998) |
| adverse drug reaction reporting systems | Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions. (12 Dec 1998) |
| adverse reaction | Any undesirable or unwanted consequence of a preventive, diagnostic, or therapeutic procedure or regimen. (05 Mar 2000) |
| agar-gel reaction | <immunology> The reaction between an antibody and an antigen during an immunology lab procedure where the two are allowed to diffuse toward each other through an agar-gel medium. Lines of precipitation form in the places on the gel where the two react with each other and shows where the reaction has occurred. (09 Oct 1997) |
| alarm reaction | The various phenomena, e.g., stimulated endocrine activity, which the body exhibits as an adaptive response to injury or stress; first phase of the general adaptation syndrome. (05 Mar 2000) |
| aldehyde reaction | The reaction of the indole derivatives with aromatic aldehydes; e.g., tryptophan and p-dimethylaminobenzaldehyde in H2SO4 give a red-violet colour useful in assaying proteins for tryptophan content. Synonym: Ehrlich reaction. (05 Mar 2000) |