| 영문 | mutation | 한글 | 돌연변이 |
|---|---|---|---|
| 설명 | 세포의 dna 자체의 변이에 의해 일어나는 세포변이를 말한다. 이러한 경우 돌연변이로 일어난 세포는 그 이후 딸세포(daughter cell)에서도 그 변이가 여전히 유지되므로 종(species)의 변화나, 혹은 세포의 악성변환(malignant transformation)에 관여한다. |
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| 영문 | basal metabolic rate(BMR) | 한글 | 기초대사율 |
|---|---|---|---|
| 설명 | 표준 기초대사량과 비교했을 때 개체 기초대사량이 보이는 편차를 표시하는 지수. 기초대사량은 생명을 유지하는데 필요한 최소한의 에너지 대사량이며, 성과 연령이 동일한 건강인의 기초대사량은 체표면적에 비례한다. 이것을 체표면적의 법칙이라고 하며, 1882년 독일의 대사생리학자 M. 브루너에 의해 제창되었다. 체표면적은 신장과 체중에 의해 산출된다. 따라서 성-연령-신장-체중을 알면 표준기초량 Y가 산출되고 실제의 기초대사량 X는 산소소비량과 이산화탄소 발생량에서 산출된다. 그리고 X와 Y의 차이를 Y로 나눈 값(%)을 기초대사율이라고 한다. 경험적으로 얻은 BMR의 간단한 측정법도 있으며 다음과 같은 식으로 구한다. 이 식에서 맥폭이란 최고혈압과 최저혈압의 차를 말한다. BMR(%)=0.75(1분 맥박수 + 0.74×맥폭)－72. BMR이 10% 이내이면 정상범위, +10% 이상이면 기초대사항진, －10% 이하이면 기초대사 저하라고 한다. 기초대사는 공복시(식후 10시간 경과)에 안정된 상태에서 단위 시간당 이용되는 에너지의 양, 즉, 한 시간당, 몸 표면의 1m2당 또는 몸무게 1kg 당 칼로리로 나타낸다. 이것은 개인에 따라 다르며 장기간에는 거의 변화가 없지만 질병 등으로 인해 변동된다. 실측한 기초대사를 표준치와 비교함으로써 질병의 진단 등에 응용할 수 있다 BMR=(실측치-표준치)/표준치 ×100(%)로 나타낸다. |
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| 영문 | five-year survival rate | 한글 | 오년생존율 |
|---|---|---|---|
| 설명 | 1. 동일 질병의 진단 혹은 치료 후, 5년이 경과 된 뒤의 생존자수의 표현. 2. 암의 진단 또는 치료 뒤에 검사를 반복하여 5년 동안 살아 있는 사람의 백분율. 치료 후 5년 동안 생존하면 일단 치유된 것으로 간주한다. |
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| 영문 | ESR(Erythrocyte Sedimentation Rate) | 한글 | 적혈구침강속도, 혈침 |
|---|---|---|---|
| 설명 | 혈액이 응고되는 것을 방지하는 항응고제를 넣은 혈액을 침강용 유리관에 넣어 가만히 세워 두었을 때 적혈구가 가라앉는 속도를 이르는 말이다. 1918년 스웨덴의 병리학자 파레우스의 창안에 의한 것이다. 측정방법으로 여러 가지가 있는데, 국제표준법으로는 1973년 웨스터그렌법의 1시간법이 선정되었으며, 1977년 그것을 개정하여 각국에서 쓰도록 권장하고 있다. 1시간 후 침강용 유리관 위쪽의 혈장기둥의 높이를 mm로 읽어, 그것을 적혈구침강의 1시간값으로 한다. 만약 혈장과 적혈구의 경계가 선명하지 못한 경우, 적혈구의 밀도가 그 이하에서는 일정하다고 여겨지는 곳의 눈금을 읽어 적혈구침강의 1시간값으로 한다. 측정 때의 실내온도는 18~25도로 한다. 일반적으로 이보다 온도가 높은 경우는 혈침반응이 촉진되며, 낮은 경우는 늦어진다. 정상 값은 2~10mm(남자), 3~15mm(여자)이며 15세 이하의 어린이, 50세 이상의 고령자에서는 약간 높다. |
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| ECG | Electro-Cardio-Graphy(-Gram); 심전도 = EKG 1. Conducting System Structu... |
|---|---|
| CPR | cardiopulmonary reserve; cardiopulmonary resuscitation; centripetal rub; cerebral cortex perfusion r... |
| CSR | central supply room; chart-stimulated recall [test]; Cheyne-Stokes respiration; continued stay revie... |
| PR | by way of the rectum [Lat. per rectum]; far point [of accommodation] [Lat. punctum remotum]; palindr... |
| ARMS | adverse reaction monitoring system; amplification refractory mutation system |
| ARMS | Amplification Refractory Mutation System |
|---|---|
| MFD | Mutation frequency decline |
| RIP | Repeat Induced Point mutation |
| RSM | Restriction Site Mutation |
| SMART | Somatic Mutation And Recombination Test |
| mutation rate | The frequency with which a particular mutation appears in a population or the frequency with which any mutation appears in the whole genome of a population. Normally the context makes the precise use clear. See: fluctuation analysis. (18 Nov 1997) |
|---|
| acquired mutation | A change in a gene or chromosome that occurs in a single cell after the conception of the individual. That change is then passed along to all cells descended from that cell. Acquired mutations are involved in the development of cancer. (12 Dec 1998) |
|---|---|
| addition-deletion mutation | <molecular biology> A type of mutation that results from insertion or deletion of a single nucleotide into, or from, an open reading frame in the normal DNA sequence. Normally, the genetic code is read in the wrong frame, three nucleotides at a time, and the entire sequence downstream of the mutation, is translated into a polypeptide with a garbled amino acid sequence from the mutated codon onwards. These mutations may be induced by certain types of mutagens or may occur spontaneously and usually result in the generation, downstream, of nonsense, chain termination codons. Synonym: addition mutation, addition-deletion mutation, deletion mutation, reading-frameshift mutation. (21 Jun 2000) |
| addition mutation | <molecular biology> A type of mutation that results from insertion or deletion of a single nucleotide into, or from, an open reading frame in the normal DNA sequence. Normally, the genetic code is read in the wrong frame, three nucleotides at a time, and the entire sequence downstream of the mutation, is translated into a polypeptide with a garbled amino acid sequence from the mutated codon onwards. These mutations may be induced by certain types of mutagens or may occur spontaneously and usually result in the generation, downstream, of nonsense, chain termination codons. Synonym: addition mutation, addition-deletion mutation, deletion mutation, reading-frameshift mutation. (21 Jun 2000) |
| amber mutation | <molecular biology> A mutation from a codon which codes for an amino acid into the amber codon UAG, which normally signals that the translation of mRNA into an amino acid chain should stop. The mutation causes the amino acid chain to stop forming before it is actually completed. (09 Oct 1997) |
| back mutation | <molecular biology> A mutation that causes a mutant gene to revert to its original wild-type base sequence. Compare: forward mutation. (09 Oct 1997) |
| reading-frameshift mutation | <molecular biology> A type of mutation that results from insertion or deletion of a single nucleotide into, or from, an open reading frame in the normal DNA sequence. Normally, the genetic code is read in the wrong frame, three nucleotides at a time, and the entire sequence downstream of the mutation, is translated into a polypeptide with a garbled amino acid sequence from the mutated codon onwards. These mutations may be induced by certain types of mutagens or may occur spontaneously and usually result in the generation, downstream, of nonsense, chain termination codons. Synonym: addition mutation, addition-deletion mutation, deletion mutation, reading-frameshift mutation. (21 Jun 2000) |
| germinal mutation | A mutation in the germ cells (the cells which will undergo meiosis to form the gametes). Such mutations are therefore passed on to offspring. (09 Oct 1997) |
| germ-line mutation | Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not. (12 Dec 1998) |
| reverse mutation | <molecular biology> A mutation that causes a mutant gene to revert to its original wild-type base sequence. Compare: forward mutation. (09 Oct 1997) |
| chromosomal mutation | Can refer to any of a number of DNA mutations which results in a change in the protein encoded by the mutated gene, such as point mutations, insertion or deletion mutations (frameshift mutations), or nonsense mutations. More often this refers to mutations involving chromosomes, such as the inversion of part of one chromosome such that the inverted part no longer matches with its homologous pair, a translocation of one part of a chromosome to a different chromosome, deletions of parts of chromosomes, or accidents which happen during the division of the nucleus like the unequal portioning of chromosomes between the daughter cells. (09 Oct 1997) |
| missense mutation | <molecular biology> A mutation that alters a codon for a particular amino acid to one specifying a different amino acid. (18 Nov 1997) |
| conditional mutation | <molecular biology> A mutation that is only expressed under certain environmental conditions for example temperature sensitive mutants. (05 Jan 1998) |
| point mutation | <molecular biology> Mutation that causes the replacement of a single base pair with another pair. (18 Nov 1997) |
| polar mutation | <molecular biology> A mutation in a single gene which affects the rate of expression of other genes that are near it on a chromosome. (09 Oct 1997) |
| mutation | 1. A change in form, quality or some other characteristic. 2. <genetics> A permanent transmissible change in the genetic material, usually in a single gene. Also, an individual exhibiting such a change. Also called (in classical genetics) a sport. Origin: L. Mutatio from mutare = to change (18 Nov 1997) |
| mutation rate |
The number of mutation events per gene per unit of time (for example, per cell generation). The proportion of mutations per cell division in bacteria or single-celled organisms or the proportion of mutations per gamete in higher organisms.
출처: helios.bto.ed.ac.uk/bto/glossary/lm.htm
|
|---|---|
| mutation rate |
The average occurrence of mutations in a species per a given unit of time.
출처: www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBook...
|
| mutation rate |
the number of new mutations that occur per gene per gamete per generation.
출처: www.canine-genetics.com/glossary.htm
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|