| phosphoramide mustards | <chemical> A group of nitrogen mustard compounds which are substituted with a phosphoramide group or its derivatives. They are usually cytotoxic and used as antineoplastic agent. Pharmacological action: antineoplastic agent, alkylating. (12 Dec 1998) |
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| nitrogen mustards | <pharmacology> A series of tertiary amine compounds having vesicant properties similar to those of mustard gas. They have the general formula RN(CH2CH2Cl)2. They can alkylate compounds such as DNA and are used as the basis of cytostatic drugs for cancer chemotherapy. (18 Nov 1997) |