| 영문 | synapse | 한글 | 시냅스 |
|---|---|---|---|
| 설명 | 영국의 셰링턴(Sherrington)이 1897년 최초로 명명한 용어로써 신경세포인 뉴론과 뉴론이 만나는 곳을 의미함. 시냅스에는 화학물질의 유리에 의해 흥분을 전달하는 화학시냅스(chemical synapse)와 전기적으로 흥분이 직접 전달되는 전기 시냅스(electrical synapse)로 분류된다. 전기 시냅스는 시냅스전뉴론(presynaptic neuron)과 시냅스후뉴론(postsynaptic neuron)의 간격이 거의 없으며 전류가 쉽게 흐를 수 있는 낮은 저항의 gap junction을 형성하여 시냅스에서의 흥분전도가 일반적인 단일신경섬유나 동일세포내에서의 전기적 전도와 근본적으로 동일하다. 화학 시냅스는 시냅스전뉴론과 시냅스후뉴론사이에 약 20nm의 틈, 즉 시냅스간격(synaptic cleft)이 존재하며 전뉴론말단에는 전달물질을 내포하는 vesicle이 많이 존재하며, 시냅스전도시 전뉴론의 vesicle로부터 신경전달물질이 유리되어 확산에 의해 후뉴론의 수용체에 도달하여 결합한다. 이러한 신경전달물질의 유리에는 Ca 이온의 유입이 중요한 작용을 한다. |
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| mAChR | muscarinic acetylcholine receptor |
|---|---|
| SYN | synapse; synovitis |
| M2 | Muscarinic |
|---|---|
| mAChRs | Muscarinic ACh receptors |
| mAChR | Muscarinic acetylcholine receptor |
| mAChR | Muscarinic cholinergic receptors |
| mAChR | Muscarinic receptor |
| receptors, muscarinic | One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for muscarine over nicotine. There are several subtypes (usually m1, m2, m3...) that are characterised by their cellular actions, pharmacology, and molecular biology. (12 Dec 1998) |
|---|---|
| muscarinic | 1. Having a muscarine-like action, i.e., producing effects that resemble postganglionic parasympathetic stimulation. 2. An agent that stimulates the postganglionic parasympathetic receptor. See: muscarine, nicotinic. (05 Mar 2000) |
| muscarinic acetylcholine receptor | Distinct from the nicotinic ACh receptor in having no intrinsic ion channel, the receptor is formed from one protein chain with 7 transmembrane regions. The receptors produce their effect via activation of GTP-binding proteins. (18 Nov 1997) |
| muscarinic agonist | Drugs that bind to and activate muscarinic cholinergic receptors (receptors, muscarinic). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate. (12 Dec 1998) |
| muscarinic antagonist | Drugs which bind with muscarinic cholinergic receptors but do not activate them, thus preventing access to acetylcholine; examples include atropine, scopolamine, propantheline, and pirenzepine. (05 Mar 2000) |
| muscarinic antagonists | Drugs that bind to but do not activate muscarinic cholinergic receptors (receptors, muscarinic), thereby blocking the actions of endogenous acetycholine or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. Antagonists that discriminate among the various muscarinic receptor subtypes and might allow better control of peripheral and central actions are under development. (12 Dec 1998) |
| muscarinic receptor kinase | <enzyme> Phosphorylates muscarinic acetylcholine receptors and beta-adrenergic receptors Registry number: EC 2.7.- Synonym: muscarinic acetylcholine receptor kinase, machr kinase (26 Jun 1999) |
| muscarinic receptors | Membrane-bound proteins whose extracellular domain contains a recognition site for acetylcholine (ACh); combination of Ach with the receptor initiates a physiologic change (slowing of heart rate, increased glandular secretory activity and stimulation of smooth muscle contractions); changes are observed after treatment with the mushroom alkaloid, muscarine. Muscarinic receptors are to be distinguished from nicotinic receptors. (05 Mar 2000) |
| axoaxonic synapse | The synaptic junction between an axon terminal of one neuron and either the initial axon segment or an axon terminal of another nerve cell. (05 Mar 2000) |
| axodendritic synapse | The synaptic contact between an axon terminal of one nerve cell and a dendrite of another nerve cell. (05 Mar 2000) |
| axosomatic synapse | The synaptic junction of an axon terminal of one nerve cell to the cell body of another nerve cell. Synonym: pericorpuscular synapse. (05 Mar 2000) |
| rectifying synapse | <physiology> An electrical synapse at which current flow can only occur in one direction. (18 Nov 1997) |
| pericorpuscular synapse | The synaptic junction of an axon terminal of one nerve cell to the cell body of another nerve cell. Synonym: pericorpuscular synapse. (05 Mar 2000) |
| chemical synapse | <physiology> A nerve nerve or nerve muscle junction where the signal is transmitted by release from one membrane of a chemical transmitter that binds to a receptor in the second membrane. Importantly, signals only pass in one direction. (18 Nov 1997) |
| ribbon synapse | <biology, physiology> Ultrastructurally distinct type of synapse found in a variety of sensory receptor cells such as retinal photoreceptor cells, cochlear hair cells and vestibular organ receptors, as well as in a nonsensory neuron, the retinal bipolar cell. Unlike most neurons, these cells do not use regenerative action potentials but release transmitter in response to small graded potential changes. Ribbon synapses have different exocytotic machinery from conventional synapses in containing dense bars or ribbons anchored to the presynaptic membrane covered with a layer of synaptic vesices. The ribbons have been proposed to shuttle synaptic vesicles to exocytotic sites. (23 Aug 1998) |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|