| multidrug resistance |
Adaptation of tumor cells to anticancer drugs in ways that make the drugs less effective.
출처: www.stjude.org/glossary
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| multidrug resistance |
Adaptation of tumor cells to chemotherapy by eliminating the drugs faster or breaking them down so that they are no longer effective.
출처: nydailynews.healthology.com/nydailynews/15836.htm
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| multidrug resistance |
A characteristic of cells that makes them resistant to the effects of several different classes of drugs. There are several forms of drug resistance.They each are determined by genes that govern how the cell will respond to the chemical agents. One type of multidrug resistance (or MDR) involves the ability to eject several drugs out of cells. The cell outer wall or membrane of the cell contains a pump that ejects chemicals, preventing them from reaching a toxic concentration. ...
출처: cll.ucsd.edu/glossarym.htm
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| multidrug resistance |
resistance of tumor cells to several unrelated drugs after exposure to a single chemotherapy drug.
출처: www.cancer.org/docroot/GRY/GRY_0.asp
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| multidrug resistance |
Resistance of tumors or infectious agents to a wide-range of therapeutic compounds. In cancer multidrug resistance ABC-MDR proteins actively expel the cytotoxic drugs from cells, maintaining the drug level below a cell-killing threshold. Drug extrusion mediated by these primary active transporters is driven by the energy of ATP hydrolysis. The most intriguing characteristic distinguishing the ABC-MDR proteins from other mammalian transporters is their wide substrate specificity. ...
출처: www.solvo.hu/glossary.html
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