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KIPS key indicators, probes, and scoring method [for evaluating compliance with requrements for accredita...
HMW High Molecular Weight
HMWM High Molecular Weight Multimers
MW Molecular Weight
CMGS chopped meat-glucose-starch [medium]; Clinical Molecular Genetics Society
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MW 000-molecular weight
AMOVA Analyses of molecular variance
CoMFA Comparative Molecular Field Analysis
HMM High molecular mass
HMW High molecular weight
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molecular probes A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in molecular genetics to detect the presence of a complementary sequence by molecular hybridization.
(12 Dec 1998)
CancerWEB ¿µ¿µ ÀÇÇлçÀü À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
RNA probes RNA, usually prepared by transcription from cloned DNA, which complements a specific mRNA or DNA and is generally used for studies of virus genes, distribution of specific RNA in tissues and cells, integration of viral DNA into genomes, transcription, etc. Whereas DNA probes are preferred for use at a more macroscopic level for detection of the presence of DNA/RNA from specific species or subspecies, RNA probes are preferred for genetic studies. Conventional labels for the RNA probe include radioisotope labels 32p and 125i and the chemical label biotin. RNA probes may be further divided by category into plus-sense RNA probes, minus-sense RNA probes, and antisense RNA probes.
(12 Dec 1998)
nucleic acid probes Nucleic acid which complements a specific mRNA or DNA molecule, or fragment thereof; used for hybridization studies in order to identify microorganisms and for genetic studies.
(12 Dec 1998)
DNA probes Species- or subspecies-specific DNA (including complementary DNA (DNA, complementary), conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridises with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32p and 125i and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
(12 Dec 1998)
DNA probes, HLA DNA probes specific for the human leukocyte antigen genes, which represent the major histocompatibility determinants in humans. The four known loci are designated as a, b, c, and d. Specific antigens are identified by a locus notation and number, e.g., HLA-a11. The inheritance of certain HLA alleles is associated with increased risk for certain diseases (e.g., insulin-dependent diabetes mellitus).
(12 Dec 1998)
DNA probes, HPV DNA probes specific for the identification of human papilloma virus.
(12 Dec 1998)
oligonucleotide probes Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridises with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32p and 125i and the chemical label biotin.
(12 Dec 1998)
relative molecular mass The sum of the atomic weight's of all the atoms constituting a molecule; the mass of a molecule relative to the mass of a standard atom, now 12C (taken as 12.000). Relative molecular mass (Mr) is the mass relative to the dalton and has no units.
See: atomic weight.
Synonym: molecular mass, molecular weight ratio, relative molecular mass.
(05 Mar 2000)
gram-molecular weight Molecular weight expressed in grams.
Compare: mole.
(05 Mar 2000)
cloning, molecular The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
(12 Dec 1998)
models, molecular Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
(12 Dec 1998)
molecular <chemistry> Of, pertaining to or composed of molecules: a very small mass of matter.
(18 Nov 1997)
molecular behaviour <psychology> Behaviour described in small response units rather than larger ones; a specific response.
Compare: molar behaviour.
(05 Mar 2000)
molecular biology <study> The study of the biochemistry of cells, it is closely linked to cell biology, in particular the biochemistry of DNA and cogeners.
(16 Dec 1997)
molecular biophysics Biophysics concerned with membrane processes, conformational and configurational properties of macromolecules, bioelectrical phenomena, etc.
(05 Mar 2000)
molecular chaperones A family of cellular proteins that mediate the correct assembly or disassembly of other polypeptides, and in some cases their assembly into oligomeric structures, but which are not components of those final structures. It is believed that chaperone proteins assist polypeptides to self-assemble by inhibiting alternative assembly pathways that produce nonfunctional structures. Some classes of molecular chaperones are the nucleoplasmins, the chaperonins, the heat-shock proteins 70, and the heat-shock proteins 90.
(12 Dec 1998)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 1 ÆäÀÌÁö: 1
  • Molecular Probes - »õâ A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.
    Synonyms : Molecular Probe, Probe, Molecular, Probes, Molecular
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