| mevastatin | Fungal metabolite which is a potent inhibitor of HMG-CoA reductase, the rate-controlling enzyme in cholesterol biosynthesis. The drug, similar to lovastatin, pravastatin and simvastatin, is used in the treatment of hyperlipidemia. (05 Mar 2000) |
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| mevastatin hydroxylase | <enzyme> Hydroxylates ml-236b (mevastatin) to pravastatin; requires NADH-cytochrome p-450 reductase Registry number: EC 1.14.13.- Synonym: cytochrome p-450sca monoxygenase, cytochrome p-450(sca) (26 Jun 1999) |