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methylmalonyl-CoA An intermediate in the degradation of several metabolites (e.g., valine, methionine, odd-chain fatty acids, theronine); elevated in cases of pernicious anaemia.
(05 Mar 2000)
methylmalonyl-CoA epimerase <enzyme> An enzyme that catalyses the interconversion of d-methylmalonyl-CoA and l-methylmalonyl-CoA.
(05 Mar 2000)
methylmalonyl-CoA mutase <enzyme> An enzyme that catalyses the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. A block in this enzymatic conversion leads to the metabolic disease, methylmalonic aciduria.
Chemical name: (R)-2-Methyl-3-oxopropanoyl-CoA CoA-carbonylmutase
Registry number: EC 5.4.99.2
(12 Dec 1998)
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D-methylmalonyl coenzyme A hydrolase <enzyme> does not act on l-methylmalonyl-CoA
Registry number: EC 3.1.2.-
Synonym: d-methylmalonyl CoA hydrolase
(26 Jun 1999)
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