| membranoproliferative g. |
a chronic glomerulonephritis characterized by mesangial cell proliferation and irregular thickening of the glomerular capillary wall. There are two subtypes: Type I is marked by subendothelial electron-dense deposits and classical complement pathway activation, and Type II (called also dense deposit disease) is marked by heavy electron-dense deposits in the glomerular basement membrane and alternative complement pathway activation involving C3 nephritic factor. Both types occur in older children and young adults and follow a slowly progressive course with irregular remissions ultimately resulting in renal failure. Called also chronic hypocomplementemic g., lobular or lobulonodular g., and mesangiocapillary g.
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