| FMF | familial Mediterranean fever; fetal movement felt; flow microfluorometry; forced midexpiratory flow |
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| MSF | macrophage slowing factor; macrophage spreading factor; Medicins sans Frontieres [Doctors without Bo... |
| EMR | Eastern Mediterranean Region |
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| FMF | Familial Mediterranean Fever |
| MSF | Mediterranean Spotted Fever |
| mediterranean islands | Scattered islands in the mediterranean sea. The chief islands are the balearic islands (belong to spain; majorca and minorca are among these), corsica (belongs to france), crete (belongs to greece), cyprus (a republic), the cyclades, dodecanese and ionian islands (belong to greece), malta (a republic), sardinia and sicily (belong to italy). (12 Dec 1998) |
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| anaemia, mediterranean | Better known today as thalassaemia (or as beta thalassaemia or thalassaemia major).The clinical picture of this important type of anaemia was first described in 1925 by the paediatrician Thomas Benton Cooley. The name thalassaemia was coined by the Nobel Prise winning pathologist George Whipple and the professor of paediatrics Wm Bradford at U. Of Rochester because thalassa in Greek means the sea (like the Mediterrranean Sea) + -aemia means in the blood so thalassaemia means sea in the blood. Thalassaemia is not just one disease. It is a complex contingent of genetic (inherited) disorders all of which involve underproduction of haemoglobin, the indispensable molecule in red blood cells that carries oxygen. The globin part of normal adult haemoglobin is made up of 2 alpha and 2 beta polypeptide chains. In beta thalassaemia, there is a mutation (change) in both beta globin chains leading to underproduction (or absence) of beta chains, underproduction of haemoglobin, and profound anaemia. The gene for beta thalassaemia is relatively frequent in people of Mediterranean origin (for example, from Italy and Greece). Children with this disease inherit one gene for it from each parent. The parents are carriers (heterozygotes) with just one thalassaemia gene, are said to have thalassaemia minor, and are essentially normal. Their children affected with beta thalassaemia seem entirely normal at birth because at birth we still have predominantly foetal haemoglobin which does not contain beta chains. The anaemia surfaces in the first few months after birth and becomes progressively more severe leading to pallor and easy fatiguability, failure to thrive (grow), bouts of fever (due to infections) and diarrhoea. Treatment based on blood transfusions is helpful but not curative. Gene therapy will, it is hoped, be applicable to this disease. (12 Dec 1998) |
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| mediterranean anaemia | Better known today as thalassaemia (or as beta thalassaemia or thalassaemia major).the clinical picture of this important type of anaemia was first described in 1925 by the paediatrician thomas benton cooley. The name thalassaemia was coined by the nobel prise winning pathologist george whipple and the professor of paediatrics wm bradford at u. Of rochester because thalassa in greek means the sea (like the mediterrranean sea) + -aemia means in the blood so thalassaemia means sea in the blood. Thalassaemia is not just one disease. It is a complex contingent of genetic (inherited) disorders all of which involve underproduction of haemoglobin, the indispensable molecule in red blood cells that carries oxygen. The globin part of normal adult haemoglobin is made up of 2 alpha and 2 beta polypeptide chains. In beta thalassaemia, there is a mutation (change) in both beta globin chains leading to underproduction (or absence) of beta chains, underproduction of haemoglobin, and profound anaemia. The gene for beta thalassaemia is relatively frequent in people of mediterranean origin (for example, from italy and greece). Children with this disease inherit one gene for it from each parent. The parents are carriers (heterozygotes) with just one thalassaemia gene, are said to have thalassaemia minor, and are essentially normal. Their children affected with beta thalassaemia seem entirely normal at birth because at birth we still have predominantly foetal haemoglobin which does not contain beta chains. The anaemia surfaces in the first few months after birth and becomes progressively more severe leading to pallor and easy fatiguability, failure to thrive (grow), bouts of fever (due to infections) and diarrhoea. Treatment based on blood transfusions is helpful but not curative. Gene therapy will, it is hoped, be applicable to this disease. (12 Dec 1998) |
| Mediterranean exanthematous fever | An affection occurring sporadically in the Mediterranean littoral marked by a severe chill with abrupt rise of temperature, pains in the joints, tonsillitis, diarrhoea, vomiting, and, on the third to fifth day, a rash of elevated nonconfluent macules beginning on the thighs and spreading to the entire body; lasts from ten days to two weeks and then disappears by rapid lysis without desquamation; probably caused by Rickettsia conorii, like Boutonneuse fever. (05 Mar 2000) |
| mediterranean fever | See Familial Mediterranean Fever. (12 Dec 1998) |
| Mediterranean lymphoma | A spectrum of conditions ranging from a benign plasma cell hyperplasia to a highly malignant lymphoma of the small intestine. (12 Dec 1998) |
| mediterranean region | The mediterranean sea, the mediterranean islands, and the countries bordering on the sea collectively. (12 Dec 1998) |
| Mediterranean theileriosis | tropical theileriosis |
| familial mediterranean fever | An inherited intestinal disorder that is characterised by recurrent fevers and intestinal inflammation. Usually has onset between the ages of 5 and 15 years and is more common in those of Mediterranean descent. Symptoms include fevers and abdominal pain. Some may also suffer from chest pains, multiple joint pains and red swollen legs. (27 Sep 1997) |
| fever, mediterranean | See Familial Mediterranean Fever. (12 Dec 1998) |
| atlantic islands | Widely scattered islands in the atlantic ocean as far north as the azores and as far south as the south sandwich islands, with the greatest concentration found in the caribbean region. They include annobon island, ascension, canary islands, falkland islands, fernando po (also called isla de bioko and bioko), gough island, madeira, sao tome and principe, saint helena, and tristan da cunha. (12 Dec 1998) |
| pacific islands | The islands of the pacific ocean divided into micronesia, melanesia, and polynesia (including new zealand). The collective name oceania includes the aforenamed islands, adding Australia, new zealand, and the malay archipelago (indonesia). (12 Dec 1998) |
| pancreatic islands | <anatomy> Groups of cells found within the pancreas: A cells and B-cells secrete insulin and glucagon. See: D cells. (18 Nov 1997) |
| virgin islands of the united states | A group of islands in the lesser antilles in the west indies, the three main islands being st. Croix, st. Thomas, and st. John. The capital is charlotte amalie. The virgin islands were discovered by columbus in 1493. Before 1917 the u.s. Virgin islands were held by the danish and called the danish west indies but the name was changed when the united states acquired them by purchase. Virgin refers to the fact that columbus made his discovery on st. Ursula's day - virgins being her legendary companions - or to the resemblance of the chain of islands to a procession of nuns or virgins. (12 Dec 1998) |
| channel islands | A group of four british islands and several islets in the english channel off the coast of france. They are known to have been occupied prehistorically. They were a part of normandy in 933 but were united to the british crown at the time of the norman conquest in 1066. Guernsey and jersey originated noted breeds of cattle. (12 Dec 1998) |
| cpg islands | Areas of increased density of the dinucleotide sequence guanine--phosphate diester--cytosine. They form stretches of DNA several hundred base pairs long and number about 30,000 islands in the mammalian genome. They are unmethylated and the site of frequent mutations. Many of the genes with which the islands are associated are housekeeping genes that are constitutively expressed. (12 Dec 1998) |
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