| map | 1. A representation of the surface of the earth, or of some portion of it, showing the relative position of the parts represented; usually on a flat surface. Also, such a representation of the celestial sphere, or of some part of it. There are five principal kinds of projection used in making maps: the orthographic, the stereographic, the globuar, the conical, and the cylindrical, or Mercator's projection. See Projection. 2. Anything which represents graphically a succession of events, states, or acts; as, an historical map. "Thus is his cheek the map of days outworn. <botany>" (Shak) Map lichen, a lichen (Lecidea geographica) growing on stones in curious maplike figures. Origin: From F. Mappe, in mappemonde map of the world, fr. L. Mappa napkin, signal cloth; a Punic word. Cf. Apron, Napkin, Nappe. Source: Websters Dictionary (01 Mar 1998) |
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| map distance | The degree of separation of two loci on a linkage map, measured in morgans or centimorgans. (05 Mar 2000) |
| MAP kinase | Mitogen activated protein kinases. (ERKs: externally regulated kinases) Serine threonine kinases that are activated when quiescent cells are treated with mitogens and therefore potentially transmit signal for entry into cell cycle. One target is trancription factor p62TCF. MAP kinase itself can be phosphorylated by MAP kinase kinase and this may in turn be controlled by RAF 1. Confusingly, do phosphorylate microtubule-associated proteins. (18 Nov 1997) |
| MAP kinase kinase kinase | <enzyme> From pc12 cells; reactivates map kinase kinase inactivated by protein phosphatase 2a by phosphorylation of serine residues; tak1 (tgf-beta-activated kinase 1) is a member of the mapkkk family; genbank ab006787 (mouse) Registry number: EC 2.7.10.- Synonym: mapkkk, tak1 mapkkk, ask1 (kinase), apoptosis signal-regulating kinase 1 (26 Jun 1999) |
| map, contig | A map depicting the relative order of a linked library of small overlapping clones representing a complete chromosome segment. (12 Dec 1998) |
| map, linkage | A map of the genes on a chromosome based on linkage analysis. A linkage map does not show the physical distances between genes but rather their relative positions, as determined by how often two gene loci are inherited together. The closer two genes are (the more tightly they are linked), the more often they will be inherited together. Linkage distance is measured in centimorgans (cm). (12 Dec 1998) |
| map, physical | A map of the locations of identifiable landmarks on chromosomes. Physical distance is measured in base pairs. The physical map differs from the genetic map which is based purely on genetic linkage data. In the human genome, the lowest-resolution physical map is the banding patterns of the 24 different chromosomes. The highest-resolution physical map is the complete nucleotide sequence of all chromosomes, a future goal. (12 Dec 1998) |
| map-dot-fingerprint dystrophy | Fingerprint dystrophy accompanied by map-like patterns and microcystic epithelial inclusions. (05 Mar 2000) |
| MAPKAP kinase-2 reactivating kinase | <enzyme> A mapk-like enzyme; homologous to p42(mapk) and p44(mapk); activated by phosphorylation of serine/threonine and tyrosine residues Registry number: EC 2.7.1.- Synonym: mapkap kinase-2 rk (26 Jun 1999) |
| maple | <botany> A tree of the genus Acer, including about fifty species. A. Saccharinum is the rock maple, or sugar maple, from the sap of which sugar is made, in the United States, in great quantities, by evaporation; the red or swamp maple is A. Rubrum; the silver maple, A. Dasycarpum, having fruit wooly when young; the striped maple, A. Pennsylvanium, called also moosewood. The common maple of Europe is A. Campestre, the sycamore maple is A. Pseudo-platanus, and the Norway maple is A. Platanoides. Maple is much used adjectively, or as the first part of a compound; as, maple tree, maple leaf, etc. Bird's-eye maple, Curled maple, varieties of the wood of the rock maple, in which a beautiful lustrous grain is produced by the sinuous course of the fibres. Maple honey, Maple molasses, or Maple sirup, maple sap boiled to the consistency of molasses. Maple sugar, sugar obtained from the sap of the sugar maple by evaporation. Origin: AS. Mapolder, mapulder, mapol; akin to Icel. Mopurr; cf. OHG. Mazzaltra, mazzoltra, G. Massholder. Source: Websters Dictionary (01 Mar 1998) |
| maple bark disease | <radiology> Type of extrinsic allergic alveolitis, source: moldy maple bark in saw mills, organism: Cryptostroma corticale (12 Dec 1998) |
| maple sugar | Sucrose extracted from the sap of the sugar maple, Acer saccharinum. Synonym: saccharum canadense. (05 Mar 2000) |
| maple syrup urine | See: maple syrup urine disease. (05 Mar 2000) |
| maple syrup urine disease | Hereditary disease due to deficiency of an enzyme involved in amino acid metabolism, characterised by urine that smells like maple syrup. (12 Dec 1998) |
| maplike skull | Various defects in the skull, especially in the temporal bone, the anterior fossa, and orbits, forming irregular outlines resembling the national boundaries in an atlas. (05 Mar 2000) |
| macrorestriction map | <molecular biology> Map depicting the order of and distance between sites at which restriction enzymes cleave chromosomes. (09 Oct 1997) |
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| genetic map | <genetics> A map of the relative positions of genetic loci on a chromosome, determined onthe basis of how often the loci are inherited together. Distance ismeasured in centimorgans (cM). (09 Oct 1997) |
| restriction map | <molecular biology> Map of DNA showing the position of sites recognised and cut by various restriction endonucleases. (12 Jan 1998) |
| peptide map | Proteases will produce fragments of a characteristic size from a protein and this can be used as a test for the identity or otherwise of two similar sized proteins. It is possible to produce a peptide fragment map from a single gel band. (18 Nov 1997) |
| chromosomal map | A formal, stylised representation of the karyotype and of the positioning and ordering on it of those loci that have been localised by any of several mapping methods. (05 Mar 2000) |
| chromosome map | The chart of the linear array of genes on a chromosome. The Human Genome Project aims to map all of the human chromosomes. (12 Dec 1998) |
| physical map | <molecular biology> A map of the locations of identifiable landmarks on DNA (for example, restriction enzyme cutting site, genes), regardless of inheritance. Distance is measured in base pairs. For the human genome, the lowest-resolution physical map is the banding patterns on the 24 different chromosomes, the highest-resolution map wouldbe the complete nucleotide sequence of the chromosomes. (09 Oct 1997) |
| conformational map | A graphical representation in which the dihedral angle of rotation about the alpha-carbon to carbonyl-carbon bond in polypeptides is plotted against the dihedral angle of rotation about the alpha-carbon to nitrogen bond. Synonym: conformational map. (05 Mar 2000) |
| contig map | <molecular biology> A map depicting the relative order of a linked library of small overlapping clones representing a complete chromosomal segment. (10 Nov 1998) |
| contiguous map | <molecular biology> A map depicting the relative order of a linked library of small overlapping clones representing a complete chromosomal segment. (10 Nov 1998) |
| cosmid map | <molecular biology> A physical map that includes a collection of bacteria containing cosmids that carry the DNA fragments under study. (10 Nov 1998) |
| cytogenetic map | A map in which the classical bonding pattern of a chromosome is shown. (05 Mar 2000) |
| sequence-tagged site map | A map representing the order and spacing of sequence-tagged sites within a stretch of DNA. (05 Mar 2000) |
| topographic map | <anatomy, neurology> The spatially ordered projection of neurons onto their target, for example in the retino tectal projection, retinal ganglion cell axons project along the optic nerve to the contralateral tectum where they ramify to form terminal arbors. The target sites of the terminal arbors are ordered: neurons from a specific region of the retina consistently project to a specific region of the tectum, forming a map of the retina on the tectum. (18 Nov 1997) |
| y map | The array of genes on the y chromosome. Once thought to be a genetic wasteland, the y now is known to contain at least 20 genes, some of them unique to the y including the male-determining gene and male fitness genes that are active only in the testis and are thought responsible for the formation of sperm. Other genes on the y have counterparts on the x chromosome, are active in many body tissues and play crucial housekeeping roles with the cell. (12 Dec 1998) |