| splitting | In chemistry, the cleavage of a covalent bond, fragmenting the molecule involved. (05 Mar 2000) |
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| splitting enzymes | Enzyme's that, like aldolases, catalyze the conversion of a molecule into two smaller molecules without the addition or subtraction of any atoms. (05 Mar 2000) |
| splitting of heart sounds | The production of major components of the first and second heart sounds (rarely the third and fourth) due to contribution by the left-sided and right-sided valves; thus, the first heart sound would have a mitral and a tricuspid component and the second heart sound has an aortic and pulmonic component. The latter are best appreciated during respiration, with inspiration delaying the pulmonic component and producing an earlier aortic component. (05 Mar 2000) |
| kinase-splitting membranal proteinase | <enzyme> Brush-border membrane proteinase; specifically clips the native form of the catalytic subunit of camp-dependent protein kinase Registry number: EC 3.4.99.- Synonym: ksm proteinase (26 Jun 1999) |
| age-related macular degeneration | A common macular degeneration beginning with drusen of the macula and pigment disruption and sometimes leading to severe loss of central vision. (05 Mar 2000) |
| macular | Maculate 1. Relating to or marked by macules. 2. Denoting the central retina, especially the macula retinae. (05 Mar 2000) |
| macular amyloidosis | A localised form of amyloidosis cutis characterised by pruritic symmetrical brown reticulated macules, especially on the upper back; microscopically, amyloid is deposited as small subepidermal globules. (05 Mar 2000) |
| macular area | An oval area of the sensory retina, 3 by 5 mm, temporal to the optic disk corresponding to the posterior pole of the eye; at its centre is the central fovea, which contains only retinal cones. Synonym: area centralis, macula lutea, macular area, punctum luteum, Soemmerring's spot, yellow spot. (05 Mar 2000) |
| macular arteries | See: inferior macular arteriole, superior macular arteriole. (05 Mar 2000) |
| macular atrophy | Atrophoderma in which the skin becomes bag like and wrinkled. Synonym: atrophia maculosa varioliformis cutis, atrophoderma maculatum, macular atrophy, primary idiopathic macular atrophy, primary macular atrophy of skin. Origin: G. Anetos, relaxed, + derma, skin (05 Mar 2000) |
| macular coloboma | A defect of the central retina as a result of arrested development or intrauterine retinal inflammation. (05 Mar 2000) |
| macular degeneration | <ophthalmology> Breakdown or damage to a portion of the retina known as the macula. Symptoms include blurring of vision (in central visual field), colours appear dim and difficulty reading or performing work up close. (27 Sep 1997) |
| macular drusen | Excrescences of Bruch's membrane that produce a window in the retinal pigment epithelium and are a feature of age-related macular retinal degeneration. Synonym: macular drusen. (05 Mar 2000) |
| macular dystrophy | A group of disorders involving predominately the posterior portion of the ocular fundus, due to degeneration in the sensory layer of the retina, retinal pigment epithelium, Bruch's membrane, choroid, or a combination of these tissues. See: Stargardt's disease, Best's disease. (05 Mar 2000) |
| macular erythema | <paediatrics> Also called baby measles. This is a nonserious but common childhood viral infection that starts with a high fever and swollen lymph glands. After 24 hours, the fever breaks and the child develops a red rash on the neck and trunk. (27 Sep 1997) |