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macrolide 1. a chemical compound characterized by a large lactone ring containing multiple keto and hydroxyl groups.  2. any of a large group of antibacterial antibiotics containing a macrolide ring linked glycosidically to one or more sugars; they are produced by certain species of Streptomyces and inhibit protein synthesis by binding to the 50S subunits of 70S ribosomes. Examples include erythromycin, azithromycin, and clarithromycin.
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