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macroglobulin <haematology, immunology> Globulin such as IgM that has a high molecular weight 400 kD in the case of IgM, 725 kD in the case of _ 2 macroglobulin.
(18 Nov 1997)
macroglobulinaemia The presence of increased levels of macroglobulins in the circulating blood.
Waldenstrom's macroglobulinaemia, macroglobulinaemia occurring in elderly persons, characterised by proliferation of cells resembling lymphocytes or plasma cells in the bone marrow, anaemia, increased sedimentation rate, and hyperglobulinaemia with a narrow peak in gamma-globulin or b2-globulin at about 19 S units. The spleen, liver, or lymph nodes are often enlarged and there is frequently purpura or mucosal bleeding.
Synonym: hyperglobulinaemic purpura, Waldenstrom's purpura, Waldenstrom's syndrome.
(05 Mar 2000)
macroglobulins Serum globulins with high molecular weight.
(12 Dec 1998)
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