| lysyl |
the acyl radical of lysine.
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| lysyl hydroxylase |
an enzyme of the oxidoreductase class that catalyzes the hydroxylation of specific lysine residues in nascent procollagen chains; the hydroxylysine residues act as sites of attachment for disaccharide prosthetic groups and are involved in the formation of strong interchain crosslinks in collagen. The enzyme requires Fe2+, ascorbate, and α-ketoglutarate for activity. Deficiency of enzyme activity, an autosomal recessive trait, results in Ehlers-Danlos syndrome, type VI. In EC nomenclature, called procollagen-lysine 5-dioxygenase.
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| lysyl oxidase |
an enzyme of the oxidoreductase class that catalyzes the oxidative deamination of lysine and hydroxylysine residues to the corresponding aldehydes, a step in the formation of covalent crosslinks in collagens and elastins. The reaction requires pyridoxal phosphate and Cu2+; the deficiency of enzyme activity and attendant physiological consequences occurring in Ehlers-Danlos syndrome, type IX (X-linked cutis laxa) and Menkes' syndrome appear to be secondary to deficiencies in copper metabolism or transport.
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| lysyl-b. |
older name for kallidin.
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