| glucose intolerance | A pathological state in which the fasting plasma glucose level is less than 140 mg per deciliter and the 30-, 60-, or 90-minute plasma glucose concentration following a glucose tolerance test exceeds 200 mg per deciliter. This condition is seen frequently in diabetes mellitus but also occurs with other diseases. (12 Dec 1998) |
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| hereditary fructose intolerance | A metabolic error due to deficiency of hepatic fructose 1,6-bisphosphate aldolase B (which also acts on fructose 1-phosphate); the second enzyme in the specific fructose pathway; vomiting and hypoglycaemia follow ingestion of fructose; prolonged fructose ingestion in young children results in failure to thrive and in jaundice, hepatomegaly, albuminuria, aminoaciduria, and sometimes cachexia and death; autosomal recessive inheritance in most families. (05 Mar 2000) |
| intolerance | Inability to withstand, sensitivity, as to a drug. Origin: L. Tolerare = to bear (18 Nov 1997) |
| lactose intolerance | A disorder characterised by abdominal cramps and diarrhoea after the consumption of food containing lactose (for example milk, ice cream), believed to occur due to a deficiency of intestinal lactase (enzyme that breaks down lactose), may appear first in young adults who have previously tolerated milk well as infants. (27 Sep 1997) |
| fructose intolerance | An autosomal recessive fructose metabolism disorder due to deficient fructose-1-phosphate aldolase (ec 2.1.2.13) activity, resulting in accumulation of fructose-1-phosphate. The accumulated fructose-1-phosphate inhibits glycogenolysis and gluconeogenesis, causing severe hypoglycaemia following ingestion of fructose. Prolonged fructose ingestion in infants leads ultimately to hepatic failure and death. Patients develop a strong distaste for sweet food, and avoid a chronic course of the disease by remaining on a fructose- and sucrose-free diet. (12 Dec 1998) |
| lysinuric protein intolerance | An autosomal recessive disorder characterised by elevated levels of dibasic amino acids (e.g., l-lysine, l-arginine, and l-ornithine) in the urine; apparently due to a defect in dibasic amino acid transport. (05 Mar 2000) |
| acetyl-CoA - lysine N6-acetyltransferase | <enzyme> First step in catabolism of lysine by saccharomyces cerevisiae Registry number: EC 2.3.1.- Synonym: accoa lysine acetyltransferase, lysine n-6-acetyltransferase, lyc1 gene product (26 Jun 1999) |
| procollagen-lysine, 2-oxoglutarate 5-dioxygenase | <enzyme> A mixed-function oxygenase that catalyses the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilises molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. Chemical name: Procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating) Registry number: EC 1.14.11.4 (12 Dec 1998) |
| protein-lysine 6-oxidase | <enzyme> An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield peptidyl-allysyl-peptide plus ammonia & hydrogen peroxide. Chemical name: Protein-L-lysine:oxygen 6-oxidoreductase (deaminating) Registry number: EC 1.4.3.13 (12 Dec 1998) |
| hippuryl-L-lysine hydrolase | <enzyme> Cleaves basic c-terminal amino acids and hydrolyses hippuryl-l-lysine Registry number: EC 3.4.12.- (26 Jun 1999) |
| histone-lysine n-methyltransferase | <enzyme> An enzyme that catalyses the methylation of the epsilon-amino group of lysine residues in proteins to yield epsilon mono-, di-, and trimethyllysine. Chemical name: S-Adenosyl-L-methionine:histone-L-lysine N(6)-methyltransferase Registry number: EC 2.1.1.43 (12 Dec 1998) |
| N6-acetyl-beta-lysine transaminase | <enzyme> Involved in oxidative catabolism of lysine by candida maltosa; forms 2-keto-6-acetamidocaproate Registry number: EC 2.6.1.65 Synonym: n6-acetyllysine transaminase, acl-at, n6-acetyllysine 2-oxoglutarate aminotransferase (26 Jun 1999) |
| N(epsilon)-(gamma-glutamyl)lysine hydrolase | <enzyme> Enzyme which is capable of directly hydrolyzing the cross-linked isopeptide into amino acids Registry number: EC 3.4.99.- Synonym: n(epsilon)-(gamma-glutamyl)lysine peptidase, ggl peptidase (26 Jun 1999) |
| indoleacetic acid-lysine synthetase | <enzyme> ATP dependent; catalyses formation of an amide bond between the carboxyl group of indoleacetic acid and the epsilon amino group of lysine Registry number: EC 6.3.2.- Synonym: iaa-lysine synthetase, n(epsilon)-(indole-3-acetyl)-l-lysine synthetase (26 Jun 1999) |
| lactococcal lysine aminopeptidase | <enzyme> Amino acid sequence given in first source Registry number: EC 3.4.11.- Synonym: lysine aminopeptidase, lactococcus (26 Jun 1999) |