| leukoencephalopathy | White matter changes first described in children with leukaemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterised by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation. Origin: Leuko-+ G. Enkephalos, brain, + pathos, suffering (05 Mar 2000) |
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| leukoencephalopathy, progressive multifocal | Rare demyelinating disease of the central nervous system which develops in immunocompromised patients secondary to lymphoproliferative disease, immunosuppressive therapy, autoimmune disorders, or aids. It is caused by the jc virus, a polyomavirus. (12 Dec 1998) |
| progressive multifocal leukoencephalopathy | <radiology> Demyelinating disease due to papovavirus, seen in immunosuppressed hosts: lymphoma, leukaemia, AIDS, TB, sarcoidosis, organ transplant, most prominent in pareito-occipital white matter, NO contrast enhancement (12 Dec 1998) |
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| disseminated necrotizing leukoencephalopathy | <radiology> DNL: demyelination due to radiation and chemotherapy, decreased density in deep white matter, with or without peripheral, patchy enhancement, calcification: basal ganglia, grey/white junction (12 Dec 1998) |