| lepromin | An extract of tissue infected with Mycobacterium leprae used in skin tests to classify the stage of leprosy. See: lepromin reaction, test. (05 Mar 2000) |
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| lepromin reaction | A delayed hypersensitivity reaction at the site of an intradermal injection of a lepromin, such as the Dharmendra antigen or Mitsuda antigen, in a lepromin test; the reaction's, such as the Fernandez or Mitsuda reaction, are variable, occurring in 48 hours or three to five weeks, but are uniformly negative in lepromatous leprosy, borderline leprosy, and mid-borderline leprosy. (05 Mar 2000) |
| lepromin skin test | <investigation> A test for leprosy where an extract of infected tissue (antigen) is injected under the skin to determine if you have a current or recent leprosy infection. Normally, little or no skin reaction should result from the injection. A positive skin reaction indicates a leprosy infection. (27 Sep 1997) |
| lepromin test | A test utilizing an intradermal injection of a lepromin, such as the Dharmendra antigen or Mitsuda antigen, to classify the stage of leprosy based on the lepromin reaction, such as the Fernandez reaction or Mitsuda reaction; it differentiates tuberculoid leprosy, in which there is a positive delayed reaction at the injection site, from lepromatous leprosy, in which there is no reaction (i.e., a negative test result) despite the active malignant Mycobacterium leprae infection; the test is not diagnostic, since normal uninfected persons may react. (05 Mar 2000) |
Synonyms :
| lepromin |
a purified homogenate of lepromatous skin nodules containing heat-killed Mycobacterium leprae; used in a skin test of immune status in leprosy (see lepromin test, under test). Called also Mitsuda antigen.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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| lepromin r. |
see under test.
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| lepromin t. |
(for certain types of leprosy): after intradermal injection of lepromin (q.v.), a positive reaction consists of a tuberculin-type reaction at 48 to 72 hours (Fernandez reaction) or a nodular, occasionally ulcerated, lesion at 3 to 4 weeks (Mitsuda reaction). The test is not diagnostic; a large fraction of the normal population exhibits lepromin reactivity owing to sensitivity to cross-reacting antigens. In individuals known to have leprosy, lepromin reactivity is indicative of tuberculoid leprosy or borderline leprosy near the tuberculoid end of the spectrum, whereas lack of reactivity is indicative of lepromatous leprosy or near-lepromatous disease.
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