| beta-lactamase | <enzyme> An enzyme produced by some bacteria, which causes the breakdown of the active form of some penicillin antibiotics, rendering them ineffective. It causes the hydrolysis of a beta-lactam (as penicillin to penicilloic acid); found in most strains of staphylococcus bacteria that are naturally resistant to penicillin. Synonym: cephalosporinase, penicillinase. (05 Mar 2000) |
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| beta-lactamase inhibitor | <pharmacology> Drugs such as clavulanic acid, which are used to inhibit bacterial beta-lactamases; often used with a penicillin or cephalosporin to overcome drug resistance. (05 Mar 2000) |
| PPM-1 beta-lactamase | <enzyme> From a cefuroxime-resistant strain of proteus mirabilis Registry number: EC 3.5.2.- Synonym: beta-lactamase fpm-1, fujisawa proteus mirabilis oxyiminocephalosporinase (26 Jun 1999) |
| thiol beta-lactamase | <enzyme> Active site serine has been mutated to cysteine in e. Coli Registry number: EC 3.5.2.- (26 Jun 1999) |
| L49-sFv-beta-lactamase | <enzyme> A single-chain l49 (igg1) antibody fusion protein for anticancer prodrug activation; retains the antigen binding capability of monovalent l49 as well as the enzymatic activity of beta-lactamase Registry number: EC 3.5.2.- Synonym: l49-sfv-bl (26 Jun 1999) |