| keto acid | An acid containing a ketone group (-CO-) in addition to the acid group(s); alpha-keto acid refers to a 2-oxo acid (e.g., pyruvic acid); beta-keto acid refers to a 3-oxo acid (e.g., acetoacetic acid), etc. Synonym: oxo acid. Alpha-keto acid dehydrogenase, one of several distinct multienzyme complexes that catalyses the formation of an acyl-CoA derivative, CO2, and NADH from an alpha-keto acid, NAD+, and coenzyme A; maple syrup urine disease results from several different inherited defects in the mitochondrial branched chain alpha-keto acid dehydrogenase complex. (05 Mar 2000) |
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| keto- | Combining form denoting a compound containing a ketone group; replaced by oxo-in systematic nomenclature. Origin: Ger. (05 Mar 2000) |
| ketoacidemia | Hereditary disease due to deficiency of an enzyme involved in amino acid metabolism, characterised by urine that smells like maple syrup. (12 Dec 1998) |
| ketoacidosis | <biochemistry, endocrinology> Acidosis accompanied by the accumulation of ketone bodies (ketosis) in the body tissues and fluids, as in diabetic acidosis. (18 Nov 1997) |
| ketoaciduria | Excretion of urine having an elevated content of ketonic acids. (05 Mar 2000) |
| ketocholesterols | Cholesterol substituted in any position by a keto moiety. The 7-keto isomer inhibits 3-hydroxy-3-methylglutaryl-CoA reductase activity and inhibits cholesterol uptake in the coronary arteries and aorta in vitro. (12 Dec 1998) |
| ketoconazole | <drug> An antifungal medication available in pill and liquid form that is effective against a variety of fungal infections such as oral, vaginal and oesophageal thrush and cryptococcosis. Possible side effects include serious liver damage and reduced testosterone levels. (09 Oct 1997) |
| ketogenesis | Metabolic production of ketones or ketone bodies. (05 Mar 2000) |
| ketogenic | Giving rise to ketone bodies in metabolism. (05 Mar 2000) |
| ketogenic corticoids test | A colourimetric test, based on the Zimmermann reaction, which indicates metabolites or adrenal and testicular steroids excreted as 17-ketones in the urine; increased values are most striking in adrenocortical tumours, decreased values in Addison's disease or in panhypopituitarism. Synonym: ketogenic corticoids test. (05 Mar 2000) |
| ketogenic diet | A high-fat, low-carbohydrate, and normal protein diet causing ketosis. (05 Mar 2000) |
| ketogenic-antiketogenic ratio | The proportion between substances that form ketones in the body and those that form d-glucose. (05 Mar 2000) |
| ketoglutarate dehydrogenase complex | <enzyme> Chemical name: 2-Oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) Registry number: EC 1.2.4.2 (12 Dec 1998) |
| ketoglutaric acids | A family of compounds containing an oxo group with the general structure of 1,5-pentanedioic acid. (12 Dec 1998) |
| ketoheptose | A seven-carbon sugar possessing a ketone group. Synonym: heptulose. (05 Mar 2000) |
| alpha-keto acid dehydrogenase | See: alpha-keto acid dehydrogenase. Anaerobic dehydrogenase, an enzyme (usually a pyridinoenzyme) catalyzing the transfer of hydrogen from some metabolite to some acceptor molecule (e.g., NAD+, cytochrome) other than oxygen; e.g., lactate dehydrogenase's, isocitrate dehydrogenase's, and others in EC class 1, excluding those listed under aerobic dehydrogenase. (05 Mar 2000) |
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| alpha-keto acid dehydrogenase complex | See: alpha-keto acid dehydrogenase. Anaerobic dehydrogenase, an enzyme (usually a pyridinoenzyme) catalyzing the transfer of hydrogen from some metabolite to some acceptor molecule (e.g., NAD+, cytochrome) other than oxygen; e.g., lactate dehydrogenase's, isocitrate dehydrogenase's, and others in EC class 1, excluding those listed under aerobic dehydrogenase. (05 Mar 2000) |
| GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase | <enzyme> Forms GDP-l-fucose Registry number: EC 5.1.3.- Synonym: GDPkd epimerase-reductase (26 Jun 1999) |
| CDP-4-keto-6-deoxy-D-glucose-3-dehydrase | <enzyme> A pyridoxamine 5'-phosphate (pmp) dependent enzyme which catalyses the deoxygenation step in 3,6-dideoxyhexose synthesis, in which the c-3 hydroxyl group of the cdp-4-keto-6-deoxy-d-hexose intermediate is replaced by a hydrogen atom; isolated from yersinia pseudotuberculosis Registry number: EC 4.2.1.- Synonym: ckdg dehydrase, cytidine diphosphate-4-keto-6-deoxy-d-glucose-3-dehydrase, cdp-6-deoxy-l-threo-d-glycero-4-hexulose 3-dehydrase (26 Jun 1999) |
| CHO aldo-keto reductase | <enzyme> From chinese hamster ovary cell line; reduces ketones and aromatic aldehydes Registry number: EC 1.1.1.- Synonym: cho cell reductase (26 Jun 1999) |
| phospho-2-keto-3-deoxy-gluconate aldolase | <enzyme> Minor descriptor (75-84); on-line and index medicus search aldehyde-lyases (75-84) Registry number: EC 4.1.2.14 Synonym: 2-keto-3-deoxy-6-phosphogluconate aldolase, 6-phospho-2-keto-3-deoxy-d-gluconate d-glyceraldehyde-3-phosphate-lyase, kdpga (26 Jun 1999) |
| progesterone 20-keto-reductase | <enzyme> Rat liver microsome enzyme requires NADPH to form the 20beta alcohol, also forms 20alpha oh using NADH Registry number: EC 1.1.1.- Synonym: progesterone 20-reductase, progesterone 20-beta reductase (26 Jun 1999) |
| S-warfarin keto reductase | <enzyme> Rat liver microsome enzyme reduces s-warfarin to its 11s-oh product Registry number: EC 1.1.1.- Synonym: warfarin 11-reductase (26 Jun 1999) |
| dTDP-4-keto-6-deoxyglucose aminotransferase | <enzyme> Salmonella enzyme; forms dtdp-4-amino-4,6-dideoxy-d-galactose Registry number: EC 2.6.1.- Synonym: glutamate-dtdp-4-keto-6-deoxy-d-glucose transaminase, dtdp-kdg transaminase (26 Jun 1999) |
| thymidine-diphospho-4-keto-6-deoxyglucose epimerase | <enzyme> Isolated from saccharopolyspora erythraea; catalyses the formation of tdp-4-keto-l-rhamnose from thymidine-diphospho-4-keto-6-deoxy-d-glucose Registry number: EC 5.1.3.- Synonym: tdkd-glucose epimerase, tdp-4-keto-6-deoxyglucose 3,5-epimerase, kde gene product (26 Jun 1999) |
| 2-keto-3-deoxy-D-galactonate aldolase | <enzyme> Involved in the non-phosphorolytic d-galactonate catabolism in fungi; cleaves 2-keto-3-deoxy-d-galactonate to pyruvate and glyceraldehyde Registry number: EC 4.1.2.- Synonym: kdgal aldolase (26 Jun 1999) |
| 2-keto-3-deoxygluconate aldolase | <enzyme> Forms pyruvate and glyceraldehyde Registry number: EC 4.1.2.- (26 Jun 1999) |
| 2-keto-3-deoxygluconate permease | <chemical> Transports degraded pectin products into the bacterial cell Chemical name: permease, 2-keto-3-deoxygluconate Synonym: kdg permease (26 Jun 1999) |
| 2-keto-3-deoxy-L-pentonate aldolase | <enzyme> Chemical name: 2-keto-3-deoxy-l-arabonate aldolase Registry number: EC 4.1.2.18 Synonym: 3-deoxy-d-pentulosonic acid aldolase, 2-keto-3-deoxy-d-xylonate aldolase (26 Jun 1999) |
| 6-phospho-2-keto-3-deoxy-galactonate aldolase | <enzyme> Chemical name: 2-keto-3-deoxygalactonate 6-p aldolase Registry number: EC 4.1.2.21 Synonym: 2-keto-3-deoxygalactonate-6-phosphate aldolase (26 Jun 1999) |