| jun | <oncogene> Oncogene from an avian sarcoma retrovirus found in chickens carriers, and which causes fibrosarcoma tumours. The normal product of the proto-oncogene is transcription regulation factor AP-1, which is formed by dimerisation with fos via a zipper motif. The product of the oncogene causes abnormal gene transcription rates. (24 Mar 1998) |
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| juncaceous | <botany> Of. Pertaining to, or resembling, a natural order of plants (Juncaceae), of which the common rush (Juncus) is the type. See: Juncate. Source: Websters Dictionary (01 Mar 1998) |
| juncite | <paleontology> A fossil rush. Origin: L. Juncus a rush. Source: Websters Dictionary (01 Mar 1998) |
| junco | <zoology> Any bird of the genus Junco, which includes several species of North American finches. Synonym: snowbird, or blue snowbird. Source: Websters Dictionary (01 Mar 1998) |
| junction | 1. The act of joining, or the state of being joined; union; combination; coalition; as, the junction of two armies or detachments; the junction of paths. 2. The place or point of union, meeting, or junction; specifically, the place where two or more lines of railway meet or cross. Junction plate, the switch, or movable, rails, connecting one line of track with another. Origin: L. Junctio, fr. Jungere, junctum, to join: cf. F. Jonction. See Join. Source: Websters Dictionary (01 Mar 1998) |
| junction nevus | A nevus consisting of nests of melanocytes in the basal cell zone, at the junction of the epidermis and dermis, appearing as a slightly raised, small, flat, nonhairy pigmented (brown or black) tumour. Synonym: epidermic-dermic nevus. (05 Mar 2000) |
| junction of lips | The junction of the lips lateral to the angle of the mouth. Synonym: commissura labiorum, junction of lips. (05 Mar 2000) |
| junction potential | <physiology> Potential difference at the boundary between dissimilar solutions, arises from differences in diffusion constants between ions. (18 Nov 1997) |
| junctional basal lamina | <cell biology> Specialised region of the extracellular matrix surrounding a muscle cell, at the neuromuscular junction. May be responsible for localisation of acetylcholine receptors in the synaptic region and also binds acetylcholine esterase to this region (18 Nov 1997) |
| junctional complex | The attachment zone between epithelial cells, typically consisting of the zonula occludens, the zonula adherens, and the macula adherens (desmosome). (05 Mar 2000) |
| junctional cyst | A cyst of the testis arising from the structures connecting the rete testis with the epididymis. (05 Mar 2000) |
| junctional epithelium | A collar of epthelial cells attached to the tooth surface and subepithelial connective tissue found at the base of the gingival crevice. Synonym: epithelial attachment. (05 Mar 2000) |
| junctional extrasystole | An extrasystole arising from the "junctional" tissues, either the A-V node or A-V bundle. Synonym: junctional extrasystole. (05 Mar 2000) |
| junctional rhythm | Rhythms originating anywhere within the A-V junction. Formerly, "A-V nodal" or simply "nodal" rhythms. (05 Mar 2000) |
| junctional tachycardia | Supraventricular tachycardia arising from the atrioventricular junction (formerly called nodal tachycardia). (05 Mar 2000) |
| genes, jun | Retrovirus-associated DNA sequences (jun) originally isolated from the avian sarcoma virus 17 (asv 17). The proto-oncogene jun (c-jun) codes for a nuclear protein which is involved in growth-related transcriptional control. Insertion of c-jun into asv-17 or the constitutive expression of the c-jun protein produces tumourgenicity. The human c-jun gene is located at 1p31-32 on the short arm of chromosome 1. (12 Dec 1998) |
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| c-Jun amino-terminal kinase | <enzyme> A stress-activated protein kinase; 46-kD kinase that phosphorylates ser(63) and ser(73) of c-jun; similar to yeast hog1 kinase; amino acid sequence given in second source; genbank l23118 Registry number: EC 2.7.10.- Synonym: jn kinase, jnk1 protein kinase, jnk-46, jnk1 protein, jun-nh2-terminal kinase, stress-activated protein kinase 1, sap kinase-1, sapk1, p46 sap kinase, c-jun kinase-1 (26 Jun 1999) |
| proto-oncogene proteins c-jun | Cellular DNA-binding proteins encoded by the c-jun genes (genes, jun). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun. (12 Dec 1998) |
| oncogene protein p65(gag-jun) | Transforming protein coded by jun oncogenes (genes, jun). This is a gag-onc fusion protein of about 65 kD derived from avian sarcoma virus. V-jun lacks a negative regulatory domain that regulates transcription in c-jun. (12 Dec 1998) |