| isocitrate | <biochemistry> An intermediate in the tricarboxylic acid cycle (citric acid cycle). (18 Nov 1997) |
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| isocitrate dehydrogenase | <enzyme> An enzyme of the oxidoreductase class that catalyses the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires magnesium, mn2+; it is activated by ADP, citrate, and calcium, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (the NADP+ enzyme is EC 1.1.1.42.) Chemical name: Isocitrate:NAD+ oxidoreductase (decarboxylating) Registry number: EC 1.1.1.41 (12 Dec 1998) |
| isocitrate lyase | <enzyme> A key enzyme in the glyoxylate cycle. It catalyses the conversion of isocitrate to succinate and glyoxylate. Chemical name: Isocitrate glyoxylate-lyase Registry number: EC 4.1.3.1 (12 Dec 1998) |