| intergenic complementation | Complementation between pieces of genetic material that regulate the same function, such as a multienzyme pathway, but have defects in regions of separate genetic function; such complementation permits synthesis of a normal end-product. (05 Mar 2000) |
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| intergenic region | <molecular biology> DNA sequences located between genes that comprise a large percentage of the human genome with no known function. (09 Oct 1997) |
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| intergenic suppression | The situation where a primary gene and the gene that suppresses it do not lie in the same chromosomal locus. Compare: intragenic suppression. (18 Nov 1997) |
| genetic complementation | <genetics> The reappearance of wild-type characteristics in a cell or organism that has had two distinct mutations on the same chromosome. Two normal versions of two different mutant genes on different chromosomes affecting the same phenotype which, when inherited together, results in the wild-type phenotype despite the presence of mutant copies of the genes. (09 Oct 1997) |
| genetic complementation test | A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell. (12 Dec 1998) |
| complementation | <cell biology> The ability of a mutant chromosome to restore normal function to a cell that has a mutation in the homologous chromosome when a hybrid or heterokaryon is formed the explanation being that the mutations are in different cistrons and between the two a complete set of normal information is present. (18 Nov 1997) |
| complementation-fixation test | <investigation> A test for the presence of antibodies in a serum, based on whether an antigen and complement, when put together with some red blood cells, are able to destroy them. If the red blood cells are destroyed, then antibodies were not present to prevent it. If the red blood cells are not destroyed, then antibodies were present to combine with the antigen and bind the complement, making them unable to attack the red blood cells. (09 Oct 1997) |
| intragenic complementation | Complementation between pieces of genetic material, each of which has a different defect within the same locus; the resultant product of each is defective and nonfunctional, but the defective products may associate to produce a product which has some activity. (05 Mar 2000) |