| inositol trisphosphate | Inositol 1, 4, 5 trisphosphate is important as a second messenger. It is released from phosphatidyl inositol bisphosphate by the action of a specific phospholipase C enzyme (PLC_) and binds to and activates a calcium channel in the endoplasmic reticulum. (18 Nov 1997) |
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| myo-inositol-trisphosphate 3-kinase | <enzyme> Converts inositol triphosphate to 1,3,4,5-tetrakisphosphate Registry number: EC 2.7.1.127 Synonym: inositol 1,4,5-triphosphate kinase, 1,4,5-intp kinase, inositol(1,4,5)p3 3-kinase, myo-inositol 1,4,5-triphosphate-3-kinase, inositol 1,4,5-trisphosphate kinase (26 Jun 1999) |
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| myo-inositol-trisphosphate 6-kinase | <enzyme> Forms inositol 1,3,4,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate in a ratio of 5:1 Registry number: EC 2.7.1.133 Synonym: inositol 1,3,4-p3 kinase, ins 1,3,4-p3 kinase, myo-inositol 1,3,4-tris phosphate 6-kinase, inositol-1,3,4-trisphosphate 5,6-kinase, inositol-trisphosphate 6-kinase (26 Jun 1999) |
| inositol 1,3,4-trisphosphate 4-phosphatase | <enzyme> Calf brain enzyme removes 4-phosphate from inositol 1,3,4-triphosphate; does not require magnesium; not inhibited by lithium Registry number: EC 3.1.3.- Synonym: inositol 1,3,4-triphosphate 4-phosphatase, intp 4-phosphatase (26 Jun 1999) |
| inositol 1,3,4-trisphosphate 5-6 kinase | <enzyme> Consider also EC 2.7.1.133 or EC 2.7.1.139 Registry number: EC 2.7.1.- Synonym: ins(1,3,4)p3 5-6 kinase (26 Jun 1999) |
| inositol 1,4,5-trisphosphate | <chemical> Intracellular messenger formed by the action of phospholipase c on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of b kinase or calmodulin. Chemical name: D-myo-Inositol, 1,4,5-tris(dihydrogen phosphate) (12 Dec 1998) |
| inositol-1,4,5-trisphosphate 5-phosphatase | <enzyme> does not act on inositol 1,4-bisphosphate or inositol 1,3,4-trisphosphate Registry number: EC 3.1.3.56 Synonym: inositol triphosphatase, myoinositol trisphosphatase, inositol polyphosphate 5-phosphatase, ip3-5-phosphatase, inositol-1,4,5-trisphosphate 5'-phosphatase, ins(1,4,5)p3 5'-phosphatase (26 Jun 1999) |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | <enzyme> Hydrolyzes the 5-position phosphate of ptdins(3,4,5)p3 forming phosphatidylinositol-3,4-bisphosphate; an isoenzyme forms a complex with the p85/p110 form of pi 3-kinase Registry number: EC 3.1.3.- Synonym: ptdins(3,4,5)p3 5-phosphatase, pi(3,4,5)p3 5-pase (26 Jun 1999) |
| glycosyl phosphatidyl inositol | gPI anchor |
| meso-inositol | 1. Generic term for any isomer of meso-inositol in which the hydroxyl groups are so arranged that the molecule as a whole possesses a plane of symmetry and is optically inactive. 2. Former name for myo-inositol. (05 Mar 2000) |
| myo-inositol | 1,2,3,5/4,6-Inositol;a constituent of various phosphatidylinositols and the most widely distributed form of inositol found in microorganisms, higher plants, and animals. In plants, it is found as phytic acid and as phytin; partially phosphorylated and free forms occur throughout nature, and in many tissues. (05 Mar 2000) |
| myo-inositol 1,4,5-triphosphate phosphatase | <enzyme> Neutral pH optimum; magnesium dependent Registry number: EC 3.1.- Synonym: i-p3ase, inositol 1,4,5-triphosphate phosphatase (26 Jun 1999) |
| myo-inositol-1 (or 4)-monophosphatase | <enzyme> Acts on inositol 1-phosphate, inositol 3-phosphate or inositol 4-phosphate; suhb gene product from e. Coli has been sequenced; do not confuse with impa protein Registry number: EC 3.1.3.25 Synonym: 1l-myo-inositol-1-phosphate phosphohydrolase, inositol-1-phosphate phosphohydrolase, myo-inositol-1-phosphatase, inositol phosphatase, myo-inositol monophosphatase, 1l-myo-inositol-1-phosphatase, inositol monophosphatase, suhb gene product, inositol monophosphate phosphatase impa (26 Jun 1999) |
| myo-inositol-1-phosphate dehydrogenase | <enzyme> Requires nad+, forms ribulose 5-phosphate Registry number: EC 1.1.1.- Synonym: inositol-1-phosphate dehydrogenase (26 Jun 1999) |
| myo-inositol-1-phosphate synthase | <enzyme> An enzyme that catalyses the formation of myo-inositol-1-phosphate from glucose-6-phosphate in the presence of NAD. Chemical name: 1L-myo-Inositol-1-phosphate lyase (isomerizing) Registry number: EC 5.5.1.4 (12 Dec 1998) |
| myo-inositol-4-phosphatase | <enzyme> Brain and liver enzymes are li-sensitive Registry number: EC 3.1.3.- (26 Jun 1999) |