| receptor mediated endocytosis | Endocytosis of molecules by means of a specific receptor protein that normally resides in a coated pit, but may enter this structure after complex formation occurs. The structure then forms a coated vesicle that delivers its contents to the endosome whence it may enter the cytoplasm or the lysosomal compartment. Many bacterial toxins and viruses enter cells by this route. (18 Nov 1997) |
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| cell-mediated immunity | <immunology> Immune response that involves effector T lymphocytes and not the production of humoral antibody. Responsible for allograft rejection, delayed hypersensitivity and in defence against viral infection and intracellular protozoan parasites. (26 Mar 1998) |
| cell-mediated reaction | Immunological reaction of the delayed type, involving chiefly T lymphocytes, important in host defense against infection, in autoimmune diseases, and in transplant rejection. See: skin test. (05 Mar 2000) |
| immune complex | <immunology> Multimolecular antibody antigen complexes that may be soluble or insoluble depending upon their size and whether or not complement is present. Immune complexes can be filtered from plasma in the kidney and the deposition of the complexes gives rise to glomerulonephritis probably because of the trapping of neutrophils via their Fc receptors. (18 Nov 1997) |
| immune complex disease | An immunologic category of diseases evoked by the deposition of antigen-antibody or antigen-antibody-complement complexes on cell surfaces, with subsequent involvement of breakdown products of complement, platelets, and polymorphonuclear leukocytes, and development of vasculitis; nephritis is common. Arthus phenomenon and serum sickness are classic examples, but many other disorders, including most of the connective tissue disease's, may belong in this immunologic category; immune complex disease's can also occur during a variety of disease's of known aetiology, such as subacute bacterial endocarditis. See: autoimmune disease. Synonym: immune complex disorder, type III hypersensitivity reaction. (05 Mar 2000) |
| immune complex diseases | Diseases characterised by the presence of immune complexes in body fluids. Hypersensitivity of the Arthus type and serum sickness are examples. (18 Nov 1997) |
| immune complex disorder | An immunologic category of diseases evoked by the deposition of antigen-antibody or antigen-antibody-complement complexes on cell surfaces, with subsequent involvement of breakdown products of complement, platelets, and polymorphonuclear leukocytes, and development of vasculitis; nephritis is common. Arthus phenomenon and serum sickness are classic examples, but many other disorders, including most of the connective tissue disease's, may belong in this immunologic category; immune complex disease's can also occur during a variety of disease's of known aetiology, such as subacute bacterial endocarditis. See: autoimmune disease. Synonym: immune complex disorder, type III hypersensitivity reaction. (05 Mar 2000) |
| immune complex glomerulonephritis | Immune complexes are deposited in the renal glomerulus where they bind complement and initiate an inflammatory process attracting neutrophils and macrophages resulting in an alteration of the basement layer of the kidney. The disease state can lead to ultimate destruction of the glomerulus and renal failure. (05 Mar 2000) |
| immune complex nephritis | An immune complex disease resulting from glomerular deposits, as in systemic lupus erythematosus. (05 Mar 2000) |
| vasculitis, hypersensitivity | Heterogeneous group of disorders characterised by a vasculitic syndrome presumed to be associated with a hypersensitivity reaction following exposure to an antigen such as an infectious agent, a drug, or other foreign or endogenous substance. (12 Dec 1998) |
| respiratory hypersensitivity | A form of hypersensitivity affecting the respiratory tract. It includes asthma and hay fever. (12 Dec 1998) |
| milk hypersensitivity | Allergic reaction to milk (usually cow's milk) or milk products. In infants the hypersensitivity is manifested by colic, vomiting, diarrhoea, rhinitis, wheezing, etc. Milk hypersensitivity should be differentiated from lactose intolerance, an intolerance to milk as a result of congenital deficiency of lactase. (12 Dec 1998) |
| contact hypersensitivity | <pathology> A type of immune-mediated inflammatory skin rash that results from an allergy to a particular substance (for example jewelry dermatitis, poison ivy, neomycin ointment, etc.). (27 Sep 1997) |
| hypersensitivity | <immunology> A state of altered reactivity in which the body reacts with an exaggerated immune response to a foreign substance. Hypersensitivity reactions are classified as immediate or delayed, types I and IV, respectively, in the Gell and Coombs classification of immune responses. (18 Nov 1997) |
| hypersensitivity, delayed | An increased reactivity to specific antigens mediated not by antibodies but by cells. (12 Dec 1998) |