| enoyl-CoA hydratase - 3-hydroxyacyl-CoA dehydrogenase - dodecanoyl-coenzyme A delta-isomerase | <chemical> Catalyses the second and third reactions of the fatty acid beta-oxidation cycle, converting enoyl-CoA to 3-ketoacyl-CoA; EC 4.2.1.17 and EC 1.1.1.35 and EC 5.3.3.8; consider also multifunctional protein-a Synonym: peroxisomal bifunctional enzyme, enoyl-coenzyme a hydratase -- 3-hydroxyacyl-coenzyme a dehydrogenase, peroxisomal trifunctional enzyme, delta(3), delta(2)-enoyl-CoA isomerase--2-enoyl-CoA hydratase--3-hydroxyacyl-CoA dehydrogenase (26 Jun 1999) |
|---|---|
| beta-hydroxyacyl-(acyl-carrier-protein)dehydrase | <enzyme> In fatty acid synthesis; specific for acyl carrier protein; cannot use acyl CoA; see also faba gene product Registry number: EC 4.2.1.- Synonym: beta-ohacyl-acp dehydrase, beta-hydroxyacyl-acyl carrier protein dehydratase, fabz gene product (26 Jun 1999) |
| short-chain beta-hydroxyacyl-CoA dehydrase | <enzyme> Forms trans-2-enoyl-CoA; maximal activity with trans-2-hexenoyl-CoA, followed by crotonyl-CoA; not the same as EC 4.2.1.17 Registry number: EC 4.2.1.- Synonym: beta-hydroxybutyryl-CoA dehydrase, short-chain beta-hydroxyacyl-coenzyme a dehydrase (26 Jun 1999) |
| D-3-hydroxyacyl CoA dehydratase | <enzyme> From rat liver peroxisomes; catalyses the epimerization of d-3-hydroxyacyl CoA by the dehydration of 3-hydroxyacyl-CoA to 2-trans-enoyl-CoA followed by the hydration of the latter enzyme to l-3-hydroxyacyl-CoA by enoyl-CoA hydratase (EC 4.2.1.17); is not active on 2-cis-enoyl CoA; consider also EC 4.2.1.74 Registry number: EC 4.2.1.- Synonym: d-3-hydroxyacyl coenzyme a dehydratase, beta-hydroxyacyl-CoA dehydratase (26 Jun 1999) |
| 3-hydroxyacyl-CoA dehydrogenase | Beta-Hydroxyacyl dehydrogenase;enzyme catalyzing the oxidation of an l-3-hydroxyacyl-CoA to a 3-ketoacyl-CoA with reduction of NAD+; one of the enzymes of the b oxidation of fatty acids. Synonym: beta-ketohydrogenase, beta-ketoreductase. (05 Mar 2000) |
| 3-hydroxyacyl CoA dehydrogenases | <enzyme> Enzymes that reversibly catalyze the oxidation of a 3-hydroxyacyl CoA to 3-ketoacyl CoA in the presence of NAD. They are key enzymes in the oxidation of fatty acids and in mitochondrial fatty acid synthesis. Chemical name: (S)-3-Hydroxyacyl-CoA:NAD+ oxidoreductase Registry number: EC 1.1.1.35 (12 Dec 1998) |
| long-chain 3-hydroxyacyl CoA dehydrogenase | <enzyme> Deficiency may cause some cases of hypoglycaemic 3-hydroxydicarboxylic aciduria Registry number: EC 1.1.1.211 Synonym: l-chad (26 Jun 1999) |
| acetoacetyl-coenzyme A | Intermediate in the oxidation of fatty acids and in the formation of ketone bodies; also formed from two molecules of acetyl-CoA; major role is condensation with acetyl-CoA to form the important beta-hydroxy-beta-methylglutaryl-CoA. Synonym: acetoacetyl-coenzyme A. (05 Mar 2000) |
| acetyl-coenzyme A | <enzyme> Condensation product of coenzyme A and acetic acid, symbolised as CoAS~COCH3; intermediate in transfer of two-carbon fragment, notably in its entrance into the tricarboxylic acid cycle and in fatty acid synthesis. This coenzyme plays a huge role in intermediary metabolism, in which cells synthesise, break down or use nutrient molecules for energy production, growth, etc. Acetyl-coenzyme A synthase is found in bacteria and plants and catalyses the reaction in which acetate enters metabolic pathways and forms acetyl-coenzyme A. Synonym: acetyl-coenzyme A, active acetate. (05 Mar 2000) |
| acetyl-coenzyme A-deacetylvindoline 4-O-acetyltransferase | <enzyme> Catalyses the final step in vindoline biosynthesis in catharanthus roseus Registry number: EC 2.3.1.107 Synonym: acadv-acetyltransferase, acetylcoenzyme a-deacetylvindoline-17-o-acetyltransferase (26 Jun 1999) |
| acetyl-coenzyme A-salutaridinol-7-O-acetyltransferase | <enzyme> Catalyses the transfer of acetyl from acetyl coenzyme a to the 7-oh group of salutaridinol which yields salutaridinol-7-o-acetate, an intermediate in morphine biosynthesis; from papaver somniferum plant cell cultures Registry number: EC 2.3.1.- Synonym: acetyl CoA-salutaridinol-7-o-acetyltransferase, salutaridinol-7-o-acetyltransferase (26 Jun 1999) |
| acyl-coenzyme A | RCH2COSCoA or RCH2CO~SCoA;condensation product of a carboxylic acid and coenzyme A, and metabolic intermediate of importance, notably in the oxidation and synthesis of fat. Synonym: acyl-coenzyme A. (05 Mar 2000) |
| arachidonoyl coenzyme A lysophosphatide acyltransferase | <enzyme> Involved in arachidonate uptake into membrane phospholipids Registry number: EC 2.3.1.- Synonym: arachidonoyl CoA lysophosphatide acyltransferase, a-CoA-l-acyltransferase (26 Jun 1999) |
| benzoate coenzyme A ligase | <enzyme> From rhodopseudomonas palustris; involved in anaerobic degradation of benzoate; high specificity for benzoate and fluorobenzoate Registry number: EC 6.2.1.25 Synonym: benzoate-CoA ligase, benzoic acid coenzyme a ligase, benzoyl-CoA ligase, benzoyl CoA synthetase (26 Jun 1999) |
| benzoyl-coenzyme A-4-oxidoreductase | <enzyme> Acts on an aromatic ch-ch bond; catalyses the conversion of 4-hydroxybenzoyl-CoA to benzoyl-CoA Registry number: EC 1.3.99.- Synonym: benzoyl-CoA-4-oxidoreductase, 4-hydroxybenzoyl-CoA reductase (dehydroxylating), hbab gene product, hbac gene product, hbad gene product (26 Jun 1999) |