| hydroxy acid | <chemistry> Any molecule which is an acid and which has a hydroxyl group (an -OH or alcohol group) attached to it. (09 Oct 1997) |
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| hydroxy acids | Organic compounds containing both the hydroxyl and carboxyl radicals. (12 Dec 1998) |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | <chemical> Alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid. An ibotenic acid homolog and glutamate agonist. The compound is the defining agonist for the ampa subtype of glutamate receptors (receptors, ampa). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies. Pharmacological action: excitatory amino acid agonists. Chemical name: 4-Isoxazolepropanoic acid, alpha-amino-2,3-dihydro-5-methyl-3-oxo- (12 Dec 1998) |
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| 12-hydroxy-5,8,10,14-eicosatetraenoic acid | A lipoxygenase metabolite of arachidonic acid. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-s-hete analog has been reported to augment tumour cell metastatic potential through activation of protein kinase c. (12 Dec 1998) |
| 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid | <chemical> A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of vasopressin and activation of phospholipase c. Pharmacological action: vasoconstrictor agents. Chemical name: 5-Heptenoic Acid, 7-(6-(3-Hydroxy-1-Ocentyl)-2-Oxabicyclo(2.2.1)hept-5-yl)-, (1R-(1alpha,4alpha,5 beta(Z),6alpha(1E,3S*)))- (12 Dec 1998) |
| 2-hydroxy-isonicotinic acid hydroxylase | <enzyme> Forms 2,6-dihydroxy-isonicotinic acid (citrazinic acid); contains iron and a flavin; incorporates hydroxyl group of water Registry number: EC 1.- Synonym: hinah (26 Jun 1999) |
| 3-hydroxy-2-pyrrolidinecarboxylic acid | A derivative of proline found in certain collagens, particularly basement membrane collagen. Synonym: 3-hydroxy-2-pyrrolidinecarboxylic acid. (05 Mar 2000) |
| 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic acid dehydrogenase | <enzyme> Nad+ dependent; from pseudomonas ma-1 grown on pyridoxine; involved in vitamin b6 degradation Registry number: EC 1.1.1.- Synonym: fhmpc dehydrogenase (26 Jun 1999) |
| 5-hydroxy-N-methylpyroglutamic acid synthetase | <enzyme> Methylamine plus alpha-ketoglutarate gives 5-hydroxy-n-methylpyroglutamic acid Registry number: EC 4.2.1.- (26 Jun 1999) |
| beta-hydroxy-beta-methylglutaryl-CoA | -OOCCH2C(OH)(CH3)CH2COS-CoA;a key intermediate in the synthesis of ketone bodies and of steroids. Synonym: 3-hydroxy-3-methylglutaryl-CoA. Beta-hydroxy-beta-methylglutaryl-lyase, an enzyme, found primarily in liver and rumen epithelium that catalyses the formation of acetyl-CoA and acetoacetate from beta-hydroxy-beta-methylglutaryl-CoA; a key step in ketogenesis; a deficiency of this enzyme leads to episodes of severe metabolic acidosis without ketosis. Beta-hydroxy-beta-methylglutaryl-reductase, an enzyme that catalyses the rate-limiting step of cholesterol biosynthesis, beta-hydroxy-beta-methylglutaryl-CoA + 2NADPH + 2H+ → mevalonate + 2NADP+ + coenzyme A. Beta-hydroxy-beta-methylglutaryl-synthase, an enzyme in mitochondria that catalyses the reaction of acetyl-CoA with acetoacetyl-CoA and water to form beta-hydroxy-beta-methylglutaryl-CoA and coenzyme A, a step required for both ketogenesis and steroidogenesis to occur. (05 Mar 2000) |
| calcium hydroxy apatite | <radiology> All calcification in soft tissues is hydroxyapatite, except cartilage (chondrocalcinosis): calcium pyrophosphate see also: Milwaukee shoulder (12 Dec 1998) |
| chromatin 3'-phosphatase-5'-hydroxy kinase | <enzyme> Hydrolyzes the 3'-phosphate end of a polynucleotide duplex followed by ATP-mediated phosphorylation of the 5'-oh end Registry number: EC 3.1.3.- Synonym: chromatin-phosphatase-hydroxykinase (26 Jun 1999) |
| S-adenosyl-L-methionine-2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase | <enzyme> Proposed pathway for final reaction in ubiquinone biosynthesis. Registry number: EC 2.1.1.- Synonym: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase, ubig gene product, ubig protein (26 Jun 1999) |
| hydroxy- | <chemistry, prefix> A combining form, also used adjectively, indicating hydroxyl as an ingredient. <chemistry> Hydroxy acid, an organic acid, having (besides the hydroxyl group of the carboxyl radical) an alcoholic hydroxyl group, and thus having the qualities of an alcohol in addition to its acid properties; as, lactic and tartaric acids are hydroxy acids. (29 Oct 1998) |
| hydroxy-Y base | <chemical> Chemical name: 1h-imidazo(1,2-a)purine-7-butanoic acid, 4,9-dihydro-beta-hydroxy-alpha-((methoxycarbonyl)amino)-4,6-dimethyl-9-oxo-, methyl ester Synonym: alpha-(carboxyamino)-beta-hydroxy-4,9-dihydro-4,6- dimethyl-9-oxo-1h-imidazo(1,2-a)purine-7-butyric acid dimethyl ester (26 Jun 1999) |
| NAD 3 alpha-hydroxy-5 alpha-pregnan-20-one-oxidoreductase | <enzyme> From rat liver microsomes Registry number: EC 1.1.1.- Synonym: nad-3-hp-20-oor (26 Jun 1999) |
| N-hydroxy-2-acetylaminofluorene N-O-acyltransferase | <enzyme> From rat liver; forms non-mutagenic n-o-acetyl-2-acetylaminofluorene Registry number: EC 2.3.1.- Synonym: n-oh-aaf n-o-acyltransferase, haf-acyltransferase (26 Jun 1999) |