| hunting | The pursuit of game or of wild animals. Happy hunting grounds, the region to which, according to the belief of American Indians, the souls of warriors and hunters pass after death, to be happy in hunting and feasting. Hunting box. Same As Hunting lodge (below). <medicine> Hunting cat, a spider which hunts its prey, instead of catching it in a web; a wolf spider. Hunting watch. See Hunter. Source: Websters Dictionary (01 Mar 1998) |
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| hunting phenomenon | An unusual reaction of digital blood vessels exposed to cold; vasoconstriction is alternated with vasodilation in irregular repeated sequences, in an apparent hunting of equilibrium of skin temperature. Synonym: hunting phenomenon. (05 Mar 2000) |
| hunting reaction | An unusual reaction of digital blood vessels exposed to cold; vasoconstriction is alternated with vasodilation in irregular repeated sequences, in an apparent hunting of equilibrium of skin temperature. Synonym: hunting phenomenon. (05 Mar 2000) |
| huntingtin | <molecular biology> Protein product of the IT15 gene that has variable numbers of polyglutamine repeats in Huntingdon's disease. The IT15 gene is widely expressed and required for nomal development. The polyglutamine repeats (44 in the commonest form of the disease) increase the interaction of huntingtin with huntingtin associated protein 1 (HAP 1) which is enriched in the brain and may be associated with pathology. Nature, 378: 398 (18 Nov 1997) |
| Huntington | George, U.S. Physician, 1850-1916. See: Huntington's chorea, Huntington's disease. (05 Mar 2000) |
| Huntington chorea | <neurology> An inherited adult-onset disease of the central nervous system. It is characterised by dementia and bizarre involuntary movements. The disease is progressive and there is currently no known cure. The identification of the gene (huntingtin) on chromosome 4p now allows for direct mutation analysis. The gene contains a trinucleotide repeat (CAG) that is found to be expanded in length in affected patients. The normal allele size ranges from 11 to 34 triplet repeat units, while 42 repeats or greater is considered diagnostic of Huntington disease. As in other trinucleotide repeat disorders, the phenomenom of anticipation has been observed, in this case expressed as earlier age of onset in offspring, particularly with paternal transmission. A further complication is the presence of two neighboring trinucleotide repeats (both CCG) which can expand independently without causing the disease. Early PCR primer sets encompassed these adjacent repeats, potentially yielding false positive test results, newer primers hone in more closely on the CAG repeat sequence. Careful attention must be paid to the psychosocial support structure of prospective test subjects in Huntington disease genetic counseling. Established protocols require systematic neuropsychiatric assessment and informed consent prior to DNA testing. Inheritance: autosomal dominant. (29 Dec 1997) |
| Huntington disease | <neurology> An inherited adult-onset disease of the central nervous system. It is characterised by dementia and bizarre involuntary movements. The disease is progressive and there is currently no known cure. The identification of the gene (huntingtin) on chromosome 4p now allows for direct mutation analysis. The gene contains a trinucleotide repeat (CAG) that is found to be expanded in length in affected patients. The normal allele size ranges from 11 to 34 triplet repeat units, while 42 repeats or greater is considered diagnostic of Huntington disease. As in other trinucleotide repeat disorders, the phenomenom of anticipation has been observed, in this case expressed as earlier age of onset in offspring, particularly with paternal transmission. A further complication is the presence of two neighboring trinucleotide repeats (both CCG) which can expand independently without causing the disease. Early PCR primer sets encompassed these adjacent repeats, potentially yielding false positive test results, newer primers hone in more closely on the CAG repeat sequence. Careful attention must be paid to the psychosocial support structure of prospective test subjects in Huntington disease genetic counseling. Established protocols require systematic neuropsychiatric assessment and informed consent prior to DNA testing. Inheritance: autosomal dominant. (29 Dec 1997) |
| Huntington's chorea | A progressive disorder usually beginning in young to middle age, consisting of a triad of choreoathetosis, dementia, and autosomal dominant inheritance with complete penetrance. Bilateral marked wasting of the putamen and the head of the caudate nucleus is characteristic. Synonym: chronic progressive chorea, degenerative chorea, hereditary chorea, Huntington's disease. (05 Mar 2000) |
| huntington's disease | An hereditary disorder with mental and physical deterioration leading to death. Although characterised as an adult-onset disease (as is usually the case), we have seen children with full-blown huntington's disease. (12 Dec 1998) |