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holoprosencephaly A birth defect that occurs during the first few weeks of intrauterine life. HPE is a disorder in which the fetal brain does not grow forward and divide as it is supposed to during early pregnancy (incomplete cleavage of the embryonic forebrain/failure of the prosencephalon to cleave into the cerebral and lateral hemispheres). This brain malformation can range from mild to severe.
Ãâó: dragon.zoo.utoronto.ca/~B03T0801B/glossary.html
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