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| VH | variable domain of heavy chain; variable heavy chain |
|---|---|
| BIC | blood isotope clearance |
| DIC | dicarbazine; differential interference contrast microscopy; diffuse intravascular coagulation; direc... |
| ICG | indocyanine green; isotope cisternography |
| ID-MS | isotope dilution-mass spectrometry |
| GC-C-IRMS | Gas chromatography-combustion-isotope ratio mass spectrometry |
|---|---|
| IDMS | Isotope dilution mass spectrometry |
| IRMS | Isotope ratio mass spectrometry |
| KIE | Kinetic isotope effects |
| RI | Radio Isotope |
| radioactive isotope | <physics, radiobiology> An isotope of an element that has an unstable nucleus, it tries to stabilise itself by giving off ionising radiation. (09 Oct 1997) |
|---|---|
| stable isotope | A nonradioactive nuclide; an isotope that shows no tendency to undergo radioactive decomposition. (05 Mar 2000) |
| daughter isotope | An element produced by radioactive decay of another. See: radionuclide generator, cow. (05 Mar 2000) |
| isotope | <radiobiology> One of several nuclides having the same number of protons in their nuclei and hence having the same atomic number, but differing in the number of neutrons and therefore, in the mass number. Almost identical chemical properties exist between isotopes of a particular element. The use of this term as a synonym for nuclide is to be discouraged. (16 Dec 1997) |
| isotope clearance | The rate at which an isotope is removed (usually by blood flow) from a tissue or organ such as the brain. (05 Mar 2000) |
| isotope labeling | Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labelled substances unless the methods of labeling are substantively discussed. Tracers that may be labelled include chemical substances, cells, or microorganisms. (12 Dec 1998) |
| gene rearrangement, b-lymphocyte, heavy chain | Ordered rearrangement of b-lymphocyte variable gene regions thereby contributing to antibody diversity. It occurs during the first stage of differentiation of the immature b-lymphocyte. (12 Dec 1998) |
| metals, heavy | metals with high specific gravity, typically larger than 5. They have complex spectra, form coloured salts and double salts, have a low electrode potential, are mainly amphoteric, yield weak bases and weak acids, and are oxidizing or reducing agents (12 Dec 1998) |
| MyoD heavy chain kinase | <enzyme> Required for actin activation of the magnesium atpase activity of dictyostelium myosin id (myod); specific for myod Registry number: EC 2.7.1.- Synonym: 110-kD protein kinase, dictyostelium, dictyostelium 110-kD protein (26 Jun 1999) |
| myosin heavy chain | <protein> See myosin: do not confuse with heavy meromyosin which is a subfragment of the heavy chain of myosin II. (18 Nov 1997) |
| myosin heavy chains | The heavy chains of the muscle protein myosin. Each molecule of myosin is composed of two heavy chains and two pairs of light chains. The heavy chains have a molecular weight of about 230 kD and each heavy chain is associated with a dissimilar pair of light chains. (devlin, textbook of biochemistry: with clinical correlations, 3rd ed, p957) (12 Dec 1998) |
| heavy | 1. Heaved or lifted with labour; not light; weighty; ponderous; as, a heavy stone; hence, sometimes, large in extent, quantity, or effects; as, a heavy fall of rain or snow; a heavy failure; heavy business transactions, etc.; often implying strength; as, a heavy barrier; also, difficult to move; as, a heavy draught. 2. Not easy to bear; burdensome; oppressive; hard to endure or accomplish; hence, grievous, afflictive; as, heavy yokes, expenses, undertakings, trials, news, etc. "The hand of the Lord was heavy upon them of Ashdod." (1 Sam. V. 6) "The king himself hath a heavy reckoning to make." (Shak) "Sent hither to impart the heavy news." (Wordsworth) "Trust him not in matter of heavy consequence." (Shak) 3. Laden with that which is weighty; encumbered; burdened; bowed down, either with an actual burden, or with care, grief, pain, disappointment. "The heavy [sorrowing] nobles all in council were." (Chapman) "A light wife doth make a heavy husband." (Shak) 4. Slow; sluggish; inactive; or lifeless, dull, inanimate, stupid; as, a heavy gait, looks, manners, style, and the like; a heavy writer or book. "Whilst the heavy plowman snores." (Shak) "Of a heavy, dull, degenerate mind." (Dryden) "Neither [is] his ear heavy, that it can not hear." (Is. Lix. 1) 5. Strong; violent; forcible; as, a heavy sea, storm, cannonade, and the like. 6. Loud; deep; said of sound; as, heavy thunder. "But, hark! that heavy sound breaks in once more." (Byron) 7. Dark with clouds, or ready to rain; gloomy; said of the sky. 8. Impeding motion; cloggy; clayey; said of earth; as, a heavy road, soil, and the like. 9. Not raised or made light; as, heavy bread. 10. Not agreeable to, or suitable for, the stomach; not easily digested; said of food. 11. Having much body or strength; said of wines, or other liquors. 12. With child; pregnant. Heavy artillery. <chemistry> See Metal. Heavy weight, in wrestling, boxing, etc, a term applied to the heaviest of the classes into which contestants are divided. Cf. Feather weight, under Feather. Heavy is used in composition to form many words which need no special explanation; as, heavy-built, heavy-browed, heavy-gaited, etc. Origin: OE. Hevi, AS. Hefig, fr. Hebban to lift, heave; akin to OHG. Hebig, hevig, Icel. Hofigr, hofugr. See Heave. Source: Websters Dictionary (01 Mar 1998) |
| heavy chain | <protein> In general, the larger polypeptide in a multimeric protein. Thus the immunoglobulin heavy chain is of 50 kD, the light chain of 22 kD, whereas in myosin the heavy chain is very much larger (220 kD) than the light chains (~20 kD). (18 Nov 1997) |
| heavy chain disease | A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the n- (amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (v) and constant (c) region genes. (12 Dec 1998) |
| heavy hydrogen | <radiobiology> Somewhat informal alternative name for deuterium. See: deuterium. (10 Jan 1998) |
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