| HCG, hCG | Human Chorionic Gonadotropin; 사람융모성성선자극호르몬 1. Placental Glycoprotein Hormone 2. Resemble LH(secreted by Pituitary gland) 3. Synthesis; Syncytiotrophoblast cell in Placenta 4. Structure; Dimer α, β MW 39,000 5. Detection 1) First; 8-9 days after ovulation(in blood) few days after implantation increase with implatation; Blood > Urine 2) Urine; 30 days 3) Peak; middle of 1st trimester 60 - 70 days(8 - 10 wks) 60 - 90 days; 100 IU/ml 10 - 12 wks after ovulation 4) Decrease; 100 - 130 days(16 - 20 wks) after ovulation에 Lower Level 도달 임신이 끝날때까지 일정 Level 유지 5) Delivery후 2 wks에 정상화 ** 분비가 증가되는 경우(Significant Higher Titer) ** 1. Multiple Fetus 2. Erythroblastosis Fetalis; maternal isoimmunization 3. H. mole 4. Choriocarcinoma; TRD(Trophoblastic Disease) 5. PIH, DM ** Significant Lower Titer ** 1. Threatened Abortion 2. Ectopic Pregnancy 3. Fetal Death 6. Function; same to LH 1) 임신 초기 유지 & promote growth of Corpus Luteum; > 2 times ** Corpus Luteum ** ; maintain pregnancy for first 2-4 Mo secretion of --Estrogen --Progesterone 1> stimulate growth of Endometrium; decidual cell growth 2> prevent menstruation 3> Involution; 13-17 wks of gestation 4> placenta; secretion of --Estrogen --Progesterone 2) stimulate secretion of testosterone by Leydig cells in fetal testis ; interstitial cell stimulating effects 1> promote formation of male sexual organs 2> descend testicules into scrotum 3> stimulate fetal testis Steroidogenesis; Cholesterol Side Chain Cleavage; 성분화 4> stimulate fetal adrenal Steroidogenesis 3) stimulate fetal ovary 4) FSH primed된 경우 stimulate ovulation; same to LH 5) Maternal Immunosuppression(Immunologic privileges); 임신 거부 반응 억제 7. Clinical Uses 1) pregnancy test; 혈중 hCG 2) 임신 초기(first trimester) 태아 발육의 Indicator 3) TRD의 Dx or Follow-Up study 8. Nisula & Ketelslegers Choriocarcinoma; high hCG --> high Thyrotropine --> Thyrotoxicosis ** Hormonal Overlap Syndrome ** TRD시 high hCG --> high TSH(유사 α-chain 구조) --> Thyrotoxicosis |
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| HCG, hCG | human chorionic gonadotropin |
| β-HCG(hCG) | Beta(β)-Human Chorionic Gonadotropin; 사람융모성성선자극호르몬 |
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