| guanylyl imidodiphosphate | <chemical> 5'-guanylic acid, monoanhydride with imidophosphoric acid. An analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. The nucleotide is a potent stimulator of adenylate cyclase. Synonym: GMP-p(nh)p; gpp(nh)p. Chemical name: 5'-Guanylic acid, monoanhydride with imidodiphosphoric acid (12 Dec 1998) |
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| adenylyl imidodiphosphate | <chemical> 5'-adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial atpase and also inhibits ATP-dependent reactions of oxidative phosphorylation. Chemical name: 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid (12 Dec 1998) |
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| guanylyl | The radical of guanylic acid. (05 Mar 2000) |
| guanylyl cyclase | <enzyme> That is responsible for catalysing the synthesis of guanosine 3', 5' cyclic monophosphate from guanosine 5' triphosphate (cyclic GMP cGMP) is used as a second messenger in heart muscle and photoreceptor cells). Plasma membrane form of guanylate cyclase is Integral membrane proteins with an extracellular receptor for peptide hormones, a transmembrane domain, a protein kinase like domain and a guanylate cyclase domain. Examples: sea urchin receptors for speract and resact and atrial natriuretic peptide receptors. Two soluble forms of guanylate cyclase are also known they are heterodimers of highly related subunits, 70-80 kD. (18 Nov 1997) |