| group A streptococcal necrotizing fasciitis | A complication of infection with GAS (group A streptococci) in which the bacteria attacks and destroys muscle tissue. According to the CDC, 5-10% of people with severe GAS infection develop necrotizing fasciitis. Though the infection can be treated with antibiotics, the fatality rate is close to 30%. This complication often develops as a wound infection after surgery or injury. (05 Mar 2000) |
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| necrotizing fasciitis | A rare soft-tissue infection primarily involving the superficial fascia and resulting in extensive undermining of surrounding tissues; progress is often fulminant and may involve all soft-tissue components, including the skin; usually occurs postoperatively, after minor trauma, or after inadequate care of abscesses or cutaneous ulcers. See: group A streptococcal necrotizing fasciitis. (05 Mar 2000) |
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| fasciitis, necrotizing | A fulminating group a streptococcal infection beginning with severe or extensive cellulitis that spreads to involve the superficial and deep fascia, producing thrombosis of the subcutaneous vessels and gangrene of the underlying tissues. A cutaneous lesion usually serves as a portal of entry for the infection, but sometimes no such lesion is found. (12 Dec 1998) |
| acute post-streptococcal glomerulonephritis | <nephrology> A disease of the kidneys that results in inflammation of the glomerulus (the portion of the kidney that filters the blood). Conditions which may cause glomerulonephritis include post-streptococcal disease (strep throat), lupus, syphilis, bacterial endocarditis, membranoproliferative glomerulonephritis, sepsis, vasculitis, Goodpasture's syndrome, typhoid fever, Henoch-Schonlein purpura, hepatitis or a viral infection (for example mumps, measles, mononucleosis). (27 Sep 1997) |
| streptococcal | Relating to or caused by any organism of the genus Streptococcus. (05 Mar 2000) |
| streptococcal fibrinolysin | <enzyme> Plasminogen activator released by Streptococcus pyogenes. Occurs in two forms, A and B. (18 Nov 1997) |
| streptococcal infections | Infections with bacteria of the genus streptococcus. (12 Dec 1998) |
| streptococcal lymphadenitis | A contagious bacterial disease of pigs caused by a group E streptococcus and characterised by the formation of abscesses in the cervical and/or cephalic lymph nodes. (05 Mar 2000) |
| streptococcal nuclease | <enzyme> From streptococcus haemolyticus; degrades RNA and DNA producing oligonucleotides terminating in 5'-phosphate Registry number: EC 3.1.30.- (26 Jun 1999) |
| streptococcal pneumonia | Pneumonia due to Streptococcus pyogenes. (05 Mar 2000) |
| streptococcal toxins | Group of haemolytic exotoxins released by Streptococci. _ haemolysin: 26-39 Kd (four types), forms ring like structures in membranes (see Streptolysin O). Lipid target unclear. _ haemolysin: a hot cold haemolysin with sphingomyelinase C activity. _ haemolysin: complex of two proteins (29 and 26 kD) that act synergistically, rabbit erythrocytes particularly sensitive. _ toxin: heat stable peptide (5 kD) with high proportion of hydrophobic amino acids. Seems to act in a detergent like manner (c.f. Subtilysin), but may form hydrophilic transmembrane pores by cooperative interaction with other _ toxin molecules. Leucocidin (Panton Valentine leucocidin): two components f (fast migration on CM cellulose column: 32 kD) and s (slow: 38 kD). Mode of action contentious. See: Streptococcus, streptolysins O and S, erythrogenic toxin. (18 Nov 1997) |
| parosteal fasciitis | A rare form of nodular fasciitis arising from the periosteum, and which may be associated with reactive cortical bone formation. (05 Mar 2000) |
| plantar fasciitis | Inflammation of the plantar fascia (fasciitis), the bowstring-like tissue stretching underneath the sole which attaches at the heel. (12 Dec 1998) |
| proliferative fasciitis | A benign rapidly-growing subcutaneous nodule characterised by proliferation of fibroblasts and basophilic giant cells slightly resembling ganglion cells. (05 Mar 2000) |
| pseudosarcomatous fasciitis | A rapidly-growing tumour-like proliferation of fibroblasts, not thought to be neoplastic, with mild inflammatory exudation occurring in fascia; the fibrosis may infiltrate surrounding tissue but does not progress indefinitely or metastasize. Synonym: pseudosarcomatous fasciitis. (05 Mar 2000) |
| nodular fasciitis | A rapidly-growing tumour-like proliferation of fibroblasts, not thought to be neoplastic, with mild inflammatory exudation occurring in fascia; the fibrosis may infiltrate surrounding tissue but does not progress indefinitely or metastasize. Synonym: pseudosarcomatous fasciitis. (05 Mar 2000) |