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giant cell a. a chronic vascular disease in the elderly, of unknown origin, often associated with polymyalgia rheumatica, seen usually in the external carotid arteries but sometimes in other arteries. Characteristics include proliferative inflammation, often with giant cells and granulomas; headache; pain with chewing; weight loss; fever; sometimes ocular symptoms; and increased erythrocyte sedimentation rate. Called also cranial, granulomatous, or temporal a. and Horton's a., disease, or syndrome.
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