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fructose bisphosphate aldolase [EC 4.1.2.13] an enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-bisphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, a reaction of the Embden-Meyerhof pathway (see illustration at pathway). The enzyme also catalyzes the conversion of fructose 1-phosphate to dihydroxyacetone phosphate and glyceraldehyde. Three isozymes are recognized: A (occurring primarily in skeletal muscle), B (in liver, kidney, small intestine, and leukocytes), and C (in brain). Isozyme B, often referred to as fructose 1-phosphate aldolase, has greater affinity for fructose 1-phosphate. Deficiency of this latter activity, an autosomal recessive trait, results in hereditary fructose intolerance. Called also aldolase.
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