| SAID | specific adaptation to imposed demand [principle] |
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| TIP | thermal inactivation point; Toxicology Information Program; translation-inhibiting protein; tumor-in... |
| TP | temperature and pressure; temperature probe; temporal peak; temporoparietal; tension pneumothorax; t... |
| PCA | Principle component analysis |
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| founder principle | The conditional probabilities of the frequencies of a set of genes at any future date depend on the initial composition of the founders of the population and have in general no tendency to revert to the composition of the population from which the founders were themselves derived. (05 Mar 2000) |
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| brass founder's ague | An occupational disease, characterised by malaria-like symptoms, due to inhalation of particles and fumes of metallic oxides. Fumes are formed by evaporation at very high temperature and condensation in air into fine particles. Synonym: brass founder's ague, foundryman's fever, metal fume fever, zinc fume fever. (05 Mar 2000) |
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| brass founder's fever | An occupational disease, characterised by malaria-like symptoms, due to inhalation of particles and fumes of metallic oxides. Fumes are formed by evaporation at very high temperature and condensation in air into fine particles. Synonym: brass founder's ague, foundryman's fever, metal fume fever, zinc fume fever. (05 Mar 2000) |
| effect, founder | A population group with an unusual frequency of a gene due to there having been only a small number of original members ( founders ) one or more of whom had that gene. For example, the gene for Huntington disease was introduced into the Lake Maracaibo region of Venezuela early in the 19th century, so there are now over a hundred persons with Huntington disease and at least 900 persons at risk for that deadly disease in that region, the largest known aggregation known in the world with the Huntington gene. (12 Dec 1998) |
| founder | <veterinary> A lameness in the foot of a horse, occasioned by inflammation; closh. An inflammatory fever of the body, or acute rheumatism; as, chest founder. Source: Websters Dictionary (01 Mar 1998) |
| founder cell | Cell that gives rise to tissue by clonal expansion. For most mammalian tissues there are considerably more than two founder cells, as can be determined by forming chimeras from genetically distinguishable embryos, but single founder cells have been found for the intestine and germ line in Caenorhabditis elegans. (18 Nov 1997) |
| founder effect | The establishment of a new population by a few original founders (in an extreme case, by a single fertilized female) which carry only a small fraction of the total genetic variation of the parental population [Ernst Mayr, 1963]. The result is that a given allele, gene, chromosome, or part of a chromosome found in members of the population can be traced back to one ancestral individual. (09 Oct 1997) |
| active principle | A constituent of a drug, usually an alkaloid or glycoside, upon the presence of which the characteristic therapeutic action of the substance largely depends. (05 Mar 2000) |
| antianaemic principle | The material in liver (and certain other tissues) that stimulates haemopoiesis in pernicious anaemia; for practical purposes, the antianaemic effect of extracts from such tissues is approximately equivalent to the content of vitamin B12. (05 Mar 2000) |
| azygos vein principle | A principle based on the observation that animals can survive prolonged vena caval occlusion without sequelae: if blood from the azygos vein alone is permitted to enter the heart, patients are perfused during cardiac and pulmonary bypass at flows much less than the normal resting cardiac output. Synonym: low flow principle. (05 Mar 2000) |
| Bernoulli's principle | <physics> When friction is negligible, the velocity of flow of a gas or fluid through a tube is inversely related to its pressure against the side of the tube; i.e., velocity is greatest and pressure lowest at a point of constriction. Synonym: Bernoulli's principle, Bernoulli's theorem. (05 Mar 2000) |
| pain-pleasure principle | A psychoanalytic concept that, in a human's psychic functioning, he/she tends to seek pleasure and avoid pain; a term borrowed by experimental psychology to denote the same tendency of an animal in a learning situation. Synonym: pleasure principle. (05 Mar 2000) |
| reality principle | The concept that the pleasure principle in personality development is modified by the demands of external reality; the principle or force that compels the growing child to adapt to the demands of external reality. (05 Mar 2000) |
| Pauli's exclusion principle | The theory limiting the number of electrons in the orbit or shell of an atom; that it is not possible for any two electrons to have all four quantum numbers identical. (05 Mar 2000) |
| repetition-compulsion principle | In psychoanalysis, the impulse to redramatise or reenact earlier emotional experiences or situations. Synonym: principle of inertia. (05 Mar 2000) |
| melanophore-expanding principle | A polypeptide hormone secreted by the intermediate lobe of the hypophysis in humans (in neurohypophysis in certain other species) which causes dispersion of melanin by melanophores, resulting in darkening of the skin, presumably by promoting melanin synthesis; this effect is readily demonstated in some lower vertebrates, such as frogs and fish; alpha-melanotropin is an N-acetylated peptide with 13 amino acids; beta-melanotropin has 22 amino acids. Synonym: intermedin, melanocyte-stimulating hormone, melanophore-expanding principle. (05 Mar 2000) |
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